Title:
ACTIVE OXYGEN-PRODUCING ENZYME-IMITATING NANO MATERIAL HAVING SPINY STRUCTURE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/016740
Kind Code:
A1
Abstract:
An active oxygen-producing enzyme-imitating nano material having a spiny structure, and a preparation method therefor and a use thereof, relating to the field of biomedical materials. The nano material is prepared from the following raw materials in parts by weight: 1-10 parts of POD-M, 1-10 parts of hexadecyltrimethyl ammonium bromide, 0.001-0.1 part of alkali, 10-100 parts of tetraethyl orthosilicate, and 100-1000 parts of cyclohexane. The POD-M is prepared from the following raw materials in parts by weight: 1-10 parts of copper acetate monohydrate, 1-10 parts of phosphomolybdic acid, 1-10 parts of glutamic acid, and 1-10 parts of trimesic acid. A V-POD-M nano system based on an in-situ ''capture-killing'' (LCK) sterilization model has broad-spectrum pathogen capture and killing capability, thus providing a strategy for improving the catalytic activity for other catalytic systems, and also showing a possibility of replacing antibiotics in the application of biomedical fields such as efficient pathogen infection resistance, antibacterial implant materials, and composite stent materials.
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Inventors:
QIU LI (CN)
YANG YE (CN)
CHENG CHONG (CN)
ZHAO CHANGSHENG (CN)
MA LANG (CN)
LI SHUANG (CN)
HE CHAO (CN)
CAO SUJIAO (CN)
YANG YE (CN)
CHENG CHONG (CN)
ZHAO CHANGSHENG (CN)
MA LANG (CN)
LI SHUANG (CN)
HE CHAO (CN)
CAO SUJIAO (CN)
Application Number:
PCT/CN2020/126847
Publication Date:
January 27, 2022
Filing Date:
November 05, 2020
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
A61K9/51; A61K31/80; A61K47/04; A61P29/00; A61P31/04; C08G83/00
Domestic Patent References:
| WO2015134204A1 | 2015-09-11 |
Foreign References:
| CN110961101A | 2020-04-07 | |||
| CN111840252A | 2020-10-30 |
Other References:
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CHOI ANGELO EARVIN SY, SUSAN ROCES, NATHANIEL DUGOS, MENG-WEI WAN: "Oxidation by H2O2 of bezothiophene and dibenzothiophene over different polyoxometalate catalysts in the frame of ultrasound and mixing assisted oxidative desulfurization", FUEL, vol. 180, 12 April 2016 (2016-04-12), pages 127 - 136, XP055889194, DOI: 10.1016/j.fuel.2016.04.014
WANG WENXING, WANG PEIYUAN, TANG XUETING, ELZATAHRY AHMED A., WANG SHUWEN, AL-DAHYAN DAIFALLAH, ZHAO MENGYAO, YAO CHI, HUNG CHIN-T: "Facile Synthesis of Uniform Virus-like Mesoporous Silica Nanoparticles for Enhanced Cellular Internalization", ACS CENTRAL SCIENCE, vol. 3, no. 8, 23 August 2017 (2017-08-23), pages 839 - 846, XP055889192, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00257
WYSZOGRODZKA GABRIELA; MARSZAłEK BARTOSZ; GIL BARBARA; DOROżYńSKI PRZEMYSłAW: "Metal-organic frameworks: mechanisms of antibacterial action and potential applications", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 6, 16 April 2016 (2016-04-16), AMSTERDAM, NL , pages 1009 - 1018, XP029565581, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2016.04.009
WU HAO BIN, XIA BAO YU, YU LE, YU XIN-YAO, LOU XIONG WEN: "Porous molybdenum carbide nano-octahedrons synthesized via confined carburization in metal-organic frameworks for efficient hydrogen production", NATURE COMMUNICATIONS, vol. 6, no. 1, 1 May 2015 (2015-05-01), XP055889190, DOI: 10.1038/ncomms7512
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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