ADENOSINE DERIVATIVES AND USE THEREOF

Title:

ADENOSINE DERIVATIVES AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2002/020540

Kind Code:

A1

Abstract:

2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5'-monophosphate or salts thereof and drugs containing the same as the active ingredient. The above compounds have excellent effects of lowering ocular tension, promoting blood flow in the retina and protecting optic nerve failure and are highly soluble in water. Owing to these characteristics, the above compounds are useful as drugs such as remedies for glaucoma and ocular hypertension.

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Inventors:

KONNO TAKASHI (JP)
UEMOTO KAZUHIRO (JP)
ONUMA SHINYA (JP)
KATO YOSHIKAZU (JP)

Application Number:

PCT/JP2001/007791

Publication Date:

March 14, 2002

Filing Date:

September 07, 2001

Export Citation:

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Assignee:

TOA EIYO LTD (JP)
YAMASA CORP (JP)
KONNO TAKASHI (JP)
UEMOTO KAZUHIRO (JP)
ONUMA SHINYA (JP)
KATO YOSHIKAZU (JP)

International Classes:

A61K9/00; A61P27/06; C07H19/16; C07H19/20; (IPC1-7): C07H19/167; A61K9/08; A61K31/7076; A61P27/06; C07H19/20

Domestic Patent References:

WO2000012098A1

2000-03-09

Foreign References:

EP0488336A1	1992-06-03
JPH059197A	1993-01-19
JPH059198A	1993-01-19
JPS57140716A	1982-08-31

Other References: