Title:
AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE
Document Type and Number:
WIPO Patent Application WO/2003/080556
Kind Code:
A1
Abstract:
The present invention relates to an amine derivative of formula I, its isomer, racemate or optical isomer, pharmaceutical salt, its amide or ester, a medicinal composition containing these, and the preparation of the same. The invention also relates to the use of these compounds in preparing medicines for preventing or treating cardiovascular diseases, diabetes, bronchus and urinary system smooth muscle convulsion, and nerve damage due to ischemia and anoxia. These compounds can be used to treat hypertension, angina, cardiac infraction, congestive heart-failure, arrhythmia, diabetes, bronchial spasm diseases, bladder or ureter spasm diseases, and depression.
Inventors:
WANG HAI (CN)
YANG RIFANG (CN)
LONG CHAOLIANG (CN)
YUN LIUHONG (CN)
CUI WENYU (CN)
WANG LIN (CN)
FENG HUASONG (CN)
GAO QIXIU (CN)
LU XINQIANG (CN)
LI FULIN (CN)
HU GANG (CN)
LIU LIJUN (CN)
TANG XINGCHUN (CN)
ZHAO RUSHENG (CN)
YAN YUAN (CN)
HE HUAMEI (CN)
LIU WEI (CN)
YANG RIFANG (CN)
LONG CHAOLIANG (CN)
YUN LIUHONG (CN)
CUI WENYU (CN)
WANG LIN (CN)
FENG HUASONG (CN)
GAO QIXIU (CN)
LU XINQIANG (CN)
LI FULIN (CN)
HU GANG (CN)
LIU LIJUN (CN)
TANG XINGCHUN (CN)
ZHAO RUSHENG (CN)
YAN YUAN (CN)
HE HUAMEI (CN)
LIU WEI (CN)
Application Number:
PCT/CN2002/000029
Publication Date:
October 02, 2003
Filing Date:
January 21, 2002
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
WANG HAI (CN)
YANG RIFANG (CN)
LONG CHAOLIANG (CN)
YUN LIUHONG (CN)
CUI WENYU (CN)
WANG LIN (CN)
FENG HUASONG (CN)
GAO QIXIU (CN)
LU XINQIANG (CN)
LI FULIN (CN)
HU GANG (CN)
LIU LIJUN (CN)
TANG XINGCHUN (CN)
ZHAO RUSHENG (CN)
YAN YUAN (CN)
HE HUAMEI (CN)
LIU WEI (CN)
WANG HAI (CN)
YANG RIFANG (CN)
LONG CHAOLIANG (CN)
YUN LIUHONG (CN)
CUI WENYU (CN)
WANG LIN (CN)
FENG HUASONG (CN)
GAO QIXIU (CN)
LU XINQIANG (CN)
LI FULIN (CN)
HU GANG (CN)
LIU LIJUN (CN)
TANG XINGCHUN (CN)
ZHAO RUSHENG (CN)
YAN YUAN (CN)
HE HUAMEI (CN)
LIU WEI (CN)
International Classes:
A61K31/13; A61K31/131; A61K31/132; A61K31/136; A61K31/137; A61K31/16; A61K31/165; A61K31/18; A61K31/405; A61K31/455; A61P1/06; A61P3/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P13/06; A61P17/12; A61P25/00; A61P25/08; A61P25/24; A61P25/28; A61P43/00; C07B61/00; C07C209/04; C07C209/28; C07C211/08; C07C211/09; C07C211/17; C07C211/21; C07C211/27; C07C213/04; C07C215/08; C07C231/02; C07C233/11; C07C235/34; C07C237/06; C07C237/20; C07C243/02; C07C303/38; C07C311/16; C07D209/20; C07D213/82; (IPC1-7): C07C211/08; C07C211/17; C07C211/09; C07C211/18; C07C229/06; C07C233/64; C07C215/00; C07C311/17; C07D213/82; C07C209/18; C07D233/44; C07D295/15; C07D263/28; A61K31/13
Foreign References:
| JPS5013321A | 1975-02-12 | |||
| US3168567A | 1965-02-02 | |||
| US3067101A | 1962-12-04 | |||
| GB873780A | 1961-07-26 | |||
| US3152180A | 1964-10-06 | |||
| US3673249A | 1972-06-27 |
Other References:
DATABASE CA [online] BROWN HERBERT C. ET AL.: "Chiral synthesis via organoboranes. 28. Reaction of alpha-chiral organyl dichloro-boranes with organyl azides providing a synthesis of secondary amines with exceptionally high enantiomeric purities", XP002976897, accession no. STN Database accession no. 114:62158
DATABASE CA [online] GOLOVNYA R.V. ET AL.: "Calculation of the gas-chromatographic retention indexes of secondary aliphatic amines from structural fragments", XP002976898, accession no. STN Database accession no. 96:210106
LIU WEI; WANG HAI; XIAO WEN-BIN: "Effects of pinacidil and nifedipine on cardiac functions in rats", BULL ACAD MIL MED SCI, vol. 20, no. 4, 1996, pages 245 - 248
M.S. DUNN; B.M. SMART; HOUBEN-WEYL, ORG. SYNTH., vol. IV, XI/2, 1963, pages 55
J.B. HENDRICKSON; R.BERGERON, TETRAHEDRON LETT., 1973, pages 3839
D.M. BALCOM; C.R. NOLLER, ORG. SYNTH., vol. IV, 1963, pages 603
CESARE FERRI, REAKTIONEN DER ORGANISCHEN SYNTHESE, 1978, pages 85
KLUSENER P.A.A; TIPL; BRANDSMA, TETRAHEDRON, 1991, pages 2041
KLUSENER P.A.A, J. CHEM. SOC., CHEM. COMMUN., 1985, pages 1677
O. C. DERMER; G. E. HAM: "Ethylenimine and other Aziridines", 1969, ACADEMIC PRESS
L.B. CLAPP, J. AMER. CHEM. SOC., vol. 70, 1948, pages 184
MING ZHAO, CHIN. J. MED. CHEM., vol. 5, no. 2, 1995, pages 91
GU MINGDI; PENG SHIPI; YU XUEMIN, J. CHIN. PHARM. SCI., vol. 2, no. 2, 1993, pages 102
See also references of EP 1386908A4
DATABASE CA [online] GOLOVNYA R.V. ET AL.: "Calculation of the gas-chromatographic retention indexes of secondary aliphatic amines from structural fragments", XP002976898, accession no. STN Database accession no. 96:210106
LIU WEI; WANG HAI; XIAO WEN-BIN: "Effects of pinacidil and nifedipine on cardiac functions in rats", BULL ACAD MIL MED SCI, vol. 20, no. 4, 1996, pages 245 - 248
M.S. DUNN; B.M. SMART; HOUBEN-WEYL, ORG. SYNTH., vol. IV, XI/2, 1963, pages 55
J.B. HENDRICKSON; R.BERGERON, TETRAHEDRON LETT., 1973, pages 3839
D.M. BALCOM; C.R. NOLLER, ORG. SYNTH., vol. IV, 1963, pages 603
CESARE FERRI, REAKTIONEN DER ORGANISCHEN SYNTHESE, 1978, pages 85
KLUSENER P.A.A; TIPL; BRANDSMA, TETRAHEDRON, 1991, pages 2041
KLUSENER P.A.A, J. CHEM. SOC., CHEM. COMMUN., 1985, pages 1677
O. C. DERMER; G. E. HAM: "Ethylenimine and other Aziridines", 1969, ACADEMIC PRESS
L.B. CLAPP, J. AMER. CHEM. SOC., vol. 70, 1948, pages 184
MING ZHAO, CHIN. J. MED. CHEM., vol. 5, no. 2, 1995, pages 91
GU MINGDI; PENG SHIPI; YU XUEMIN, J. CHIN. PHARM. SCI., vol. 2, no. 2, 1993, pages 102
See also references of EP 1386908A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (2 Fuchengmenwai Steet, Beijing 7, CN)
Download PDF: