Title:
AMINOCARBOXYLIC ACID DERIVATIVE, ADDITION SALT THEREOF, AND S1P RECEPTOR CONTROL AGENT
Document Type and Number:
WIPO Patent Application WO/2005/044780
Kind Code:
A1
Abstract:
An aminocarboxylic acid derivative represented by the general formula (1) (example: 3-amino-6-[4-(3-benzyloxyphenylsulfanyl)-2-chlorophenyl]-3-hydroxymethylhexanoic acid). It is highly effective in controlling a sphingosine-1-phosphoric acid (S1P) receptor.
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Inventors:
KOHNO YASUSHI (JP)
TANIOKA SAYOKO (JP)
KIKUCHI YOSHIAKI (JP)
KINOSHITA MIKI (JP)
IWANAMI SATORU (JP)
TANIOKA SAYOKO (JP)
KIKUCHI YOSHIAKI (JP)
KINOSHITA MIKI (JP)
IWANAMI SATORU (JP)
Application Number:
PCT/JP2004/016517
Publication Date:
May 19, 2005
Filing Date:
November 08, 2004
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
KOHNO YASUSHI (JP)
TANIOKA SAYOKO (JP)
KIKUCHI YOSHIAKI (JP)
KINOSHITA MIKI (JP)
IWANAMI SATORU (JP)
KOHNO YASUSHI (JP)
TANIOKA SAYOKO (JP)
KIKUCHI YOSHIAKI (JP)
KINOSHITA MIKI (JP)
IWANAMI SATORU (JP)
International Classes:
C07C229/34; C07C229/36; C07C229/42; C07C317/22; C07C317/50; C07C323/20; C07C323/41; C07C323/63; C07F7/18; (IPC1-7): C07C233/47; A61K31/195; A61K31/197; A61K31/198; A61P1/04; A61P1/16; A61P7/02; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P13/12; A61P17/02; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07C317/50; C07C323/63; C07F7/18; C07M7/00
Domestic Patent References:
| WO2003073986A2 | 2003-09-12 | |||
| WO1996006068A1 | 1996-02-29 | |||
| WO2002076995A2 | 2002-10-03 | |||
| WO2002008189A1 | 2002-01-31 |
Foreign References:
| JP2001515483A | 2001-09-18 | |||
| JPH09504547A | 1997-05-06 | |||
| JP2003523339A | 2003-08-05 | |||
| JP2000502050A | 2000-02-22 | |||
| JPH0570495A | 1993-03-23 |
Other References:
KIUCHI ET AL: "Synthesis and Immunosuppressive Activity of 2-substituted 2-Aminopropane-1, 3-diols and 2-Aminoethanols", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 15, 2000, pages 2946 - 2961, XP002271142
HINTERDING ET AL: "Synthesis of Chiral Analogues of FTY720 and its Phosphate", SYNTHESIS, vol. 11, 12 August 2003 (2003-08-12), pages 1667 - 1670, XP002986959
LONG ET AL: "Enantioselectie syntheses of homophenylalanine derivatives via nitrone 1, 3-dipolar cycloaddition reactions with styrenes", TETRAHEDRON LETTERS, vol. 42, no. 32, 2001, pages 5343 - 5345, XP004254955
COLLIER ET AL: "The direct synthesis of novel enantiomerically pure alpha-amino acids in protected form via Suzuki cross-coupling", TETRAHEDRON LETTERS, vol. 41, no. 36, 2000, pages 7115 - 7119, XP004208272
KLEIN ET AL: "Total Synthesis and Antifungal Evaluation of Cyclic Amino hexapeptides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 7, 2000, pages 1677 - 1696, XP002319425
CAMPBELL ET AL: "The Synthesis of Novel Amino Acids via Hydroboration-Suzuki Cross Coupling", TETRAHEDRON LETTERS, vol. 40, no. 28, 1999, pages 5263 - 5266, XP004170069
HASHIMOTO ET AL: "beta-Phenylselenoalanine as a dehydroalanine precursor-efficient synthesis of alternariolide (AM-toxin I)", CHEMICAL COMMUNICATIONS, vol. 10, 1996, pages 1139 - 1140, XP002986960
HINTERDING ET AL: "Synthesis of Chiral Analogues of FTY720 and its Phosphate", SYNTHESIS, vol. 11, 12 August 2003 (2003-08-12), pages 1667 - 1670, XP002986959
LONG ET AL: "Enantioselectie syntheses of homophenylalanine derivatives via nitrone 1, 3-dipolar cycloaddition reactions with styrenes", TETRAHEDRON LETTERS, vol. 42, no. 32, 2001, pages 5343 - 5345, XP004254955
COLLIER ET AL: "The direct synthesis of novel enantiomerically pure alpha-amino acids in protected form via Suzuki cross-coupling", TETRAHEDRON LETTERS, vol. 41, no. 36, 2000, pages 7115 - 7119, XP004208272
KLEIN ET AL: "Total Synthesis and Antifungal Evaluation of Cyclic Amino hexapeptides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 7, 2000, pages 1677 - 1696, XP002319425
CAMPBELL ET AL: "The Synthesis of Novel Amino Acids via Hydroboration-Suzuki Cross Coupling", TETRAHEDRON LETTERS, vol. 40, no. 28, 1999, pages 5263 - 5266, XP004170069
HASHIMOTO ET AL: "beta-Phenylselenoalanine as a dehydroalanine precursor-efficient synthesis of alternariolide (AM-toxin I)", CHEMICAL COMMUNICATIONS, vol. 10, 1996, pages 1139 - 1140, XP002986960
Attorney, Agent or Firm:
Kishida, Masayuki (Marunouchi-Yaesu Building 6-2, Marunouchi
2-chome, Chiyoda-k, Tokyo 05, JP)
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