Title:
ANTIBODY AGAINST HUMAN KGFR
Document Type and Number:
WIPO Patent Application WO/2001/079266
Kind Code:
A1
Abstract:
A polyclonal antibody specifically binding to human keratinocyte growth factor receptor (KGFR). Because of having a high specificity to KGFR, this antibody makes it possible to accurately and quickly detect and determine KGFR in various organs, tissues and cells. Thus, it is usable in detecting and immunoassaying various tumors such as pearl tumor.
Inventors:
KOJI TAKEHIKO (JP)
NAKAMURA MITSURU (JP)
NAKAMURA MITSURU (JP)
Application Number:
PCT/JP2000/008736
Publication Date:
October 25, 2001
Filing Date:
December 11, 2000
Export Citation:
Assignee:
NICHIREI KK (JP)
KOJI TAKEHIKO (JP)
NAKAMURA MITSURU (JP)
KOJI TAKEHIKO (JP)
NAKAMURA MITSURU (JP)
International Classes:
C12N15/09; C07K7/08; C07K14/71; C07K16/28; C12P21/08; G01N33/68; C12R1/91; (IPC1-7): C07K7/08; C07K16/28; G01N33/53; G01N33/68
Other References:
BOTTARO DONALD P. ET AL.: "A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 13, May 1993 (1993-05-01), pages 9180 - 9183, XP002937849
MIKI TORU ET AL.: "Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop", SCIENCE, vol. 251, 4 January 1991 (1991-01-04), pages 72 - 75, XP002937850
MIKI TORU ET AL.: "Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene", PROC. NATL. ACAD. SCI. USA, vol. 89, no. 1, January 1992 (1992-01-01), pages 246 - 250, XP002937851
ZHOU JIE ET AL.: "Keratinocyte growth factor down-regulates expression of the sucrase-isomaltase gene in Caro-2 intestinal epithelial cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33367 - 33373, XP002937852
ISHIWATA TOSHIYUKI ET AL.: "Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer", AMERICAN JOURNAL OF PATHOLOGY, vol. 153, no. 1, July 1998 (1998-07-01), pages 213 - 222, XP002937853
MIKI TORU ET AL.: "Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop", SCIENCE, vol. 251, 4 January 1991 (1991-01-04), pages 72 - 75, XP002937850
MIKI TORU ET AL.: "Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene", PROC. NATL. ACAD. SCI. USA, vol. 89, no. 1, January 1992 (1992-01-01), pages 246 - 250, XP002937851
ZHOU JIE ET AL.: "Keratinocyte growth factor down-regulates expression of the sucrase-isomaltase gene in Caro-2 intestinal epithelial cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33367 - 33373, XP002937852
ISHIWATA TOSHIYUKI ET AL.: "Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer", AMERICAN JOURNAL OF PATHOLOGY, vol. 153, no. 1, July 1998 (1998-07-01), pages 213 - 222, XP002937853
Attorney, Agent or Firm:
Hiraki, Yusuke (Toranomon 1-chome Minato-ku Tokyo, JP)
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