Title:
ARYLFORMAMIDE COMPOUND AND PREPARATION METHOD AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/238834
Kind Code:
A1
Abstract:
The present invention relates to an arylformamide compound and a preparation method and a medical use thereof. Particularly, the present invention relates to a compound shown in a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound and a use thereof as a P2X3 receptor antagonist. The compound and the pharmaceutical composition containing the compound can be used for treating and/or preventing diseases related to P2X3 activity, such as chronic cough, pain, endometriosis, overactive bladder etc. The definition of each substituent in the general formula (I) is the same as that in the specification.
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Inventors:
YIN HUIJUN (CN)
YAN XU (CN)
ZONG LIBIN (CN)
LIU GUOBIAO (CN)
ZHANG SHOULIANG (CN)
CHEN BIN (CN)
YAN XU (CN)
ZONG LIBIN (CN)
LIU GUOBIAO (CN)
ZHANG SHOULIANG (CN)
CHEN BIN (CN)
Application Number:
PCT/CN2021/095424
Publication Date:
December 02, 2021
Filing Date:
May 24, 2021
Export Citation:
Assignee:
THE NAT INSTITUTES OF PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
C07D417/12; A61K31/415; A61K31/427; A61P11/00; A61P25/28; C07D401/12; C07D417/14
Domestic Patent References:
| WO2020260463A1 | 2020-12-30 | |||
| WO2019219672A1 | 2019-11-21 | |||
| WO2019219674A1 | 2019-11-21 |
Foreign References:
| CN107207507A | 2017-09-26 | |||
| US20150080408A1 | 2015-03-19 | |||
| US20170057932A1 | 2017-03-02 | |||
| US20170081320A1 | 2017-03-23 | |||
| US20170056398A1 | 2017-03-02 | |||
| CN102574778A | 2012-07-11 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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