Title:
BIOMARKER FOR DETERMINING FERTILITY, AND DETERMINING METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/149410
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a biomarker by which embryos having a high implantation/pregnancy probability, i.e., having high fertility can be selected from among embryos obtained by in vitro fertilization and then embryo culturing in infertility treatment; and a determination criterion thereof. The present invention provides a criterion with which an egg suitable for implantation/pregnancy can be determined, by measuring the concentration of soluble CD163 present in a follicular fluid to be collected simultaneously with the egg at the time of egg collection in infertility treatment or in a serum immediately before the egg collection.
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Inventors:
MIYAGI ETSUKO (JP)
MURASE MARIKO (JP)
HAYAMA TOMONARI (JP)
RYO AKIHIDE (JP)
HORIUCHI YAYOI (JP)
KOBORI HIROKI (JP)
OHTAKE NORIHISA (JP)
MURASE MARIKO (JP)
HAYAMA TOMONARI (JP)
RYO AKIHIDE (JP)
HORIUCHI YAYOI (JP)
KOBORI HIROKI (JP)
OHTAKE NORIHISA (JP)
Application Number:
PCT/JP2021/045799
Publication Date:
July 14, 2022
Filing Date:
December 13, 2021
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
TOSOH CORP (JP)
TOSOH CORP (JP)
International Classes:
C07K16/28; C07K14/705; C12N15/12; G01N33/50; G01N33/53; G01N33/68
Domestic Patent References:
| WO2008084105A1 | 2008-07-17 | |||
| WO2016170021A1 | 2016-10-27 | |||
| WO2011060080A2 | 2011-05-19 | |||
| WO2018003995A1 | 2018-01-04 |
Foreign References:
| JP2018513979A | 2018-05-31 | |||
| JP2017510250A | 2017-04-13 | |||
| JP2013510575A | 2013-03-28 | |||
| JP2010515909A | 2010-05-13 | |||
| JP2017158579A | 2017-09-14 | |||
| JP2016173366A | 2016-09-29 | |||
| US20020155995A1 | 2002-10-24 |
Other References:
ANONYMOUS: "Human Soluble CD163 (sCD163) Assay Kit", FUNAKOSHI CO., LTD., 22 May 2006 (2006-05-22), XP055949790, Retrieved from the Internet
VOGEL IDA, ET AL.: "Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery", BJOG, vol. 112, no. 6, 30 June 2005 (2005-06-30), pages 737 - 742, XP055949794, DOI: 10.1111/j.1471-0528.2005.00557.x
DIAO LIANGHUI, CAI SONGCHEN, HUANG CHUNYU, LI LONGFEI, YU SHUYI, WANG LINLIN, LIU SU, LI YUYE, ZENG YONG: "New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI", PLACENTA, W.B. SAUNDERS, GB, vol. 99, 1 September 2020 (2020-09-01), GB , pages 180 - 188, XP055949795, ISSN: 0143-4004, DOI: 10.1016/j.placenta.2020.07.025
YIN, YONG-XIANG: "Expression of CD68 and CD163 in unexplained infertility endometrial tissue", GUANGDONG YIXUE, vol. 35, no. 10, 1 January 2014 (2014-01-01), CN , pages 1600 - 1602, XP009538197, ISSN: 1001-9448
SHARPS MEGAN C., ET AL.: "Increased placental macrophages and a pro-inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 84, no. 3, 31 May 2000 (2000-05-31), pages e13267, XP055949799, DOI: 10.1111/aji.13267
TANAKA, AYAKA: "O-154 Probucol results with Scavenger receptor class B type I (SR‐BI) deficient apolipoprotein E (ApoE) low gene mutations in mouse fertility", JOURNAL OF JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE, JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE, JP, vol. 62, no. 4, 1 October 2017 (2017-10-01), JP , pages 216 (378), XP009538321, ISSN: 1881-0098
A. KOLMAKOVA, J. WANG, R. BROGAN, C. CHAFFIN, A. RODRIGUEZ: "Deficiency of Scavenger Receptor Class B Type I Negatively Affects Progesterone Secretion in Human Granulosa Cells", ENDOCRINOLOGY, ASSOCIATION FOR THE STUDY OF INTERNAL SECRETIONS, vol. 151, no. 11, 1 November 2010 (2010-11-01), pages 5519 - 5527, XP055090573, ISSN: 00137227, DOI: 10.1210/en.2010-0347
XU JERRY Z, KUMAR RAMESH, GONG HAOLI, LIU LUYAO, RAMOS-SOLIS NICOLE, LI YUJING, DERBIGNY WILBERT A, XU CITATION, JZ, KUMAR R, G: "Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells", INFECTION AND IMMUNITY, vol. 87, no. 10, 31 October 2019 (2019-10-31), pages e00483 - 19, XP055949804, DOI: 10.1128/IAI.00483-19
FAN XIANGXIU; YANG YUANYUAN; WEN QUAN; LI YUAN; MENG FEI; LIAO JINGNAN; CHEN HUIJUN; LU GUANG-XIU; LIN GE; GONG FEI: "CD19 and intraglandular CD163-positivity as prognostic indicators of pregnancy outcome in CD138-negative women with a previous fresh-embryo-transfer failure", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ELSEVIER SCIENCE IRELAND LTD., IE, vol. 147, 26 August 2021 (2021-08-26), IE , XP086783545, ISSN: 0165-0378, DOI: 10.1016/j.jri.2021.103362
TAVARES PEREIRA MIGUEL, NOWACZYK RENATA, PAYAN-CARREIRA RITA, MIRANDA SONIA, ASLAN SELIM, KAYA DUYGU, KOWALEWSKI MARIUSZ P.: "Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog", FRONTIERS IN VETERINARY SCIENCE, vol. 7, 1 January 2021 (2021-01-01), pages 625921, XP055949805, DOI: 10.3389/fvets.2020.625921
"Opinion on the Prevention of Multiple Pregnancy in Artificial Reproductive Technology", OBSTETRICIANS AND GYNECOLOGISTS, April 2008 (2008-04-01)
ATLAS OF THE HUMAN OOCYTE & EARLY CONCEPTUS, 1991, pages 2
GARDNER DK ET AL., FERTIL. STERIL., vol. 73, 2000, pages 1155 - 1158
PRIBENSZKY ET AL., REPROD. BIOMED. ONLINE, vol. 35, no. 5, 2017, pages 511 - 520
VOGEL IDA, ET AL.: "Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery", BJOG, vol. 112, no. 6, 30 June 2005 (2005-06-30), pages 737 - 742, XP055949794, DOI: 10.1111/j.1471-0528.2005.00557.x
DIAO LIANGHUI, CAI SONGCHEN, HUANG CHUNYU, LI LONGFEI, YU SHUYI, WANG LINLIN, LIU SU, LI YUYE, ZENG YONG: "New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI", PLACENTA, W.B. SAUNDERS, GB, vol. 99, 1 September 2020 (2020-09-01), GB , pages 180 - 188, XP055949795, ISSN: 0143-4004, DOI: 10.1016/j.placenta.2020.07.025
YIN, YONG-XIANG: "Expression of CD68 and CD163 in unexplained infertility endometrial tissue", GUANGDONG YIXUE, vol. 35, no. 10, 1 January 2014 (2014-01-01), CN , pages 1600 - 1602, XP009538197, ISSN: 1001-9448
SHARPS MEGAN C., ET AL.: "Increased placental macrophages and a pro-inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 84, no. 3, 31 May 2000 (2000-05-31), pages e13267, XP055949799, DOI: 10.1111/aji.13267
TANAKA, AYAKA: "O-154 Probucol results with Scavenger receptor class B type I (SR‐BI) deficient apolipoprotein E (ApoE) low gene mutations in mouse fertility", JOURNAL OF JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE, JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE, JP, vol. 62, no. 4, 1 October 2017 (2017-10-01), JP , pages 216 (378), XP009538321, ISSN: 1881-0098
A. KOLMAKOVA, J. WANG, R. BROGAN, C. CHAFFIN, A. RODRIGUEZ: "Deficiency of Scavenger Receptor Class B Type I Negatively Affects Progesterone Secretion in Human Granulosa Cells", ENDOCRINOLOGY, ASSOCIATION FOR THE STUDY OF INTERNAL SECRETIONS, vol. 151, no. 11, 1 November 2010 (2010-11-01), pages 5519 - 5527, XP055090573, ISSN: 00137227, DOI: 10.1210/en.2010-0347
XU JERRY Z, KUMAR RAMESH, GONG HAOLI, LIU LUYAO, RAMOS-SOLIS NICOLE, LI YUJING, DERBIGNY WILBERT A, XU CITATION, JZ, KUMAR R, G: "Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells", INFECTION AND IMMUNITY, vol. 87, no. 10, 31 October 2019 (2019-10-31), pages e00483 - 19, XP055949804, DOI: 10.1128/IAI.00483-19
FAN XIANGXIU; YANG YUANYUAN; WEN QUAN; LI YUAN; MENG FEI; LIAO JINGNAN; CHEN HUIJUN; LU GUANG-XIU; LIN GE; GONG FEI: "CD19 and intraglandular CD163-positivity as prognostic indicators of pregnancy outcome in CD138-negative women with a previous fresh-embryo-transfer failure", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ELSEVIER SCIENCE IRELAND LTD., IE, vol. 147, 26 August 2021 (2021-08-26), IE , XP086783545, ISSN: 0165-0378, DOI: 10.1016/j.jri.2021.103362
TAVARES PEREIRA MIGUEL, NOWACZYK RENATA, PAYAN-CARREIRA RITA, MIRANDA SONIA, ASLAN SELIM, KAYA DUYGU, KOWALEWSKI MARIUSZ P.: "Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog", FRONTIERS IN VETERINARY SCIENCE, vol. 7, 1 January 2021 (2021-01-01), pages 625921, XP055949805, DOI: 10.3389/fvets.2020.625921
"Opinion on the Prevention of Multiple Pregnancy in Artificial Reproductive Technology", OBSTETRICIANS AND GYNECOLOGISTS, April 2008 (2008-04-01)
ATLAS OF THE HUMAN OOCYTE & EARLY CONCEPTUS, 1991, pages 2
GARDNER DK ET AL., FERTIL. STERIL., vol. 73, 2000, pages 1155 - 1158
PRIBENSZKY ET AL., REPROD. BIOMED. ONLINE, vol. 35, no. 5, 2017, pages 511 - 520
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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