Title:
BONE REGENERATION PROMOTING COMPOSITION AND BONE REGENERATION PROMOTING APPARATUS
Document Type and Number:
WIPO Patent Application WO/2017/154855
Kind Code:
A1
Abstract:
[Problem] To provide a composition and apparatus for promoting the regeneration of bone, specifically cartilage, as well as a bone regeneration promoting method. [Solution] A bone regeneration promoting composition that includes, as active ingredients, nanobubbles of hydrogen and/or of oxygen and nitrogen. A method for promoting bone regeneration by combining the bone regeneration composition, hormesis, and spatial pressure–based therapy. A sealable chamber apparatus, the apparatus being provided with a supply means for a gas mixture of hydrogen, oxygen, and nitrogen, and a control means for the internal chamber atmospheric pressure. Additionally provided is a method for promoting bone regeneration using the apparatus.
Inventors:
KAMEI ICHIRO (JP)
ICHIHASHI KENICHI (JP)
ICHIHASHI KENICHI (JP)
Application Number:
PCT/JP2017/008860
Publication Date:
September 14, 2017
Filing Date:
March 06, 2017
Export Citation:
Assignee:
AQUA ZEST CORP (JP)
International Classes:
A61K33/00; A61P19/08; A61P43/00
Domestic Patent References:
| WO2015099201A1 | 2015-07-02 |
Foreign References:
| JP2015164910A | 2015-09-17 | |||
| JP2008296095A | 2008-12-11 | |||
| JP2008214207A | 2008-09-18 |
Other References:
HILDEBRANDT G. ET AL.: "Effects of low dose radiation therapy on adjuvant induced arthritis in rats", INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 76, no. 8, 2000, pages 1143 - 53
OSAMU INOUE ET AL.: "Kokiatsu Sanso Ryoho (HBO) no Kotsukeisei Sokushin Sayo", JOURNAL OF JAPANESE ASSOCIATION FOR CLINICAL HYPERBARIC OXYGEN AND DIVING, vol. 11, no. 1, 2014, pages 24 - 35
SHUNJI KASAI: "Effects of vitamin E on bone", VITAMINS, vol. 85, no. 11, 2011, pages 595 - 600
HO-JIN MOON ET AL.: "Coenzyme q10 regulates osteoclast and osteoblast differentiation", JOURNAL OF FOOD SCIENCE, vol. 78, no. 5, 2013, pages H785 - 891, XP055415669
PANAGIOTIS LEPETSOS ET AL.: "ROS/oxidative stress signaling in osteoarthritis", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1862, no. 4, 6 January 2016 (2016-01-06), pages 576 - 91, XP055415669
ALVIN CHAO- YU CHEN ET AL.: "Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study", JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol. 5, no. 91, 2010, pages 1 - 9, XP021090327
TOSHITSUGU KAWATA ET AL.: "Effect of insulin- like growth factor-I (IGF-I) on femoral bone modeling in growing mice", EXPERIMENTAL ANIMALS, vol. 51, no. 5, 2002, pages 521 - 4, XP055415677
ROBERT C. OLNEY ET AL.: "Growth factor regulation of human growth plate chondrocyte proliferation in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 317, no. 4, 2004, pages 1171 - 82, XP004502893
ZHIBAO MI ET AL.: "Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints", ARTHRITIS AND RHEUMATISM, vol. 43, no. 11, 2000, pages 2563 - 70, XP002985111
OSAMU INOUE ET AL.: "Kokiatsu Sanso Ryoho (HBO) no Kotsukeisei Sokushin Sayo", JOURNAL OF JAPANESE ASSOCIATION FOR CLINICAL HYPERBARIC OXYGEN AND DIVING, vol. 11, no. 1, 2014, pages 24 - 35
SHUNJI KASAI: "Effects of vitamin E on bone", VITAMINS, vol. 85, no. 11, 2011, pages 595 - 600
HO-JIN MOON ET AL.: "Coenzyme q10 regulates osteoclast and osteoblast differentiation", JOURNAL OF FOOD SCIENCE, vol. 78, no. 5, 2013, pages H785 - 891, XP055415669
PANAGIOTIS LEPETSOS ET AL.: "ROS/oxidative stress signaling in osteoarthritis", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1862, no. 4, 6 January 2016 (2016-01-06), pages 576 - 91, XP055415669
ALVIN CHAO- YU CHEN ET AL.: "Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study", JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol. 5, no. 91, 2010, pages 1 - 9, XP021090327
TOSHITSUGU KAWATA ET AL.: "Effect of insulin- like growth factor-I (IGF-I) on femoral bone modeling in growing mice", EXPERIMENTAL ANIMALS, vol. 51, no. 5, 2002, pages 521 - 4, XP055415677
ROBERT C. OLNEY ET AL.: "Growth factor regulation of human growth plate chondrocyte proliferation in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 317, no. 4, 2004, pages 1171 - 82, XP004502893
ZHIBAO MI ET AL.: "Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints", ARTHRITIS AND RHEUMATISM, vol. 43, no. 11, 2000, pages 2563 - 70, XP002985111
Attorney, Agent or Firm:
OHIRA Kazuyuki (JP)
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