Title:
CARDIOMYOCYTE AGGREGATE PRODUCTION TECHNIQUE IMPROVING SURVIVAL RATE UNDER CRYOPRESERVATION AND HYPOXIC CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2021/112374
Kind Code:
A1
Abstract:
The present invention relates to a method for enhancing the long-term preservation efficiency of cardiomyocyte aggregates. The method according to the present invention enables the cryopreservation of cardiomyocyte aggregates, and thus can not only expand the scope of 3D cell structure research, such as organoid production using pluripotent stem cells and the development of new drugs using organoids, but also enhances cell survival rates under hypoxic condition generated after in vivo transplantation, and thus is expected to be useful for related technology, such as the development of cell therapy products.
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Inventors:
MOON SUNG HWAN (KR)
PARK SOON JUNG (KR)
JUNG TAEK HEE (KR)
BAN KI WON (KR)
PARK SOON JUNG (KR)
JUNG TAEK HEE (KR)
BAN KI WON (KR)
Application Number:
PCT/KR2020/011077
Publication Date:
June 10, 2021
Filing Date:
August 20, 2020
Export Citation:
Assignee:
T & R BIOFAB CO LTD (KR)
International Classes:
C12N5/077; A01N1/02; A61K35/34; A61P9/00; C12M3/00
Foreign References:
| KR101916902B1 | 2018-11-08 | |||
| JP2010538665A | 2010-12-16 | |||
| KR20120035801A | 2012-04-16 | |||
| KR20190158572A | 2019-12-02 | |||
| KR20200091585A | 2020-07-31 |
Other References:
PARK SOON-JUNG, KIM RI YOUN, PARK BONG-WOO, LEE SUNGHUN, CHOI SEONG WOO, PARK JAE-HYUN, CHOI JONG JIN, KIM SEOK-WON, JANG JINAH, C: "Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055817786, DOI: 10.1038/s41467-019-11091-2
CAI WENXUAN, ZHANG JIANHUA, DE LANGE WILLEM J., GREGORICH ZACHERY R., KARP HANNAH, FARRELL EMILY T., MITCHELL STANFORD D., TUCHOLS: "An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 125, no. 11, 8 November 2019 (2019-11-08), US, pages 936 - 953, XP055817788, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.119.315305
CAI WENXUAN, ZHANG JIANHUA, DE LANGE WILLEM J., GREGORICH ZACHERY R., KARP HANNAH, FARRELL EMILY T., MITCHELL STANFORD D., TUCHOLS: "An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 125, no. 11, 8 November 2019 (2019-11-08), US, pages 936 - 953, XP055817788, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.119.315305
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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