Title:
CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN
Document Type and Number:
WIPO Patent Application WO/2012/116254
Kind Code:
A3
Abstract:
Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.
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Inventors:
BEWLEY CAROLE A (US)
WIPF PETER (US)
WIPF PETER (US)
Application Number:
PCT/US2012/026438
Publication Date:
December 27, 2012
Filing Date:
February 24, 2012
Export Citation:
Assignee:
US HEALTH (US)
UNIV PITTSBURGH (US)
BEWLEY CAROLE A (US)
WIPF PETER (US)
UNIV PITTSBURGH (US)
BEWLEY CAROLE A (US)
WIPF PETER (US)
International Classes:
C07C15/50; A61K31/085; C07C17/266; C07C25/24; C07C41/05; C07C43/275; C07C43/285; C07C43/295
Other References:
F. HUBALEK ET AL: "Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 16, 1 April 2005 (2005-04-01), pages 15761 - 15766, XP055027610, ISSN: 0021-9258, DOI: 10.1074/jbc.M500949200
KATHLEEN ENGLAND ET.AL.: "Substituted diphenyl etheres as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 64, 4 September 2009 (2009-09-04), pages 1052 - 1061, XP002676376
KATHLEEN ENGLAND ET.AL.: "Substituted diphenyl etheres as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 64, 4 September 2009 (2009-09-04), pages 1052 - 1061, XP002676376
Attorney, Agent or Firm:
GARDNER, Gillian (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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