CINNAMOYL AMINO ACID COMPOUNDS AND USE THEREOF

WIPO Patent Application WO/2021/189750

A1

Cinnamoyl amino acid compounds and a use thereof, which relate to the fields of medicinal chemistry and pharmacotherapeutics, and specifically relate to cinnamoyl amino acid compounds having inducible nitric oxide synthase (iNOS) inhibitory activity or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising said compounds, and a medical use thereof, particularly an application thereof in the prevention and treatment of neurodegenerative diseases related to nerve cell damage, comprising ischemic stroke, Parkinson's disease, and so on.

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WANG HAO (CN)
HU XIAOLONG (CN)
LV XIANYU (CN)
XIONG FEI (CN)
FENG JIAHAO (CN)

PCT/CN2020/107122

September 30, 2021

August 05, 2020

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UNIV CHINA PHARMA (CN)

C07C233/51; A61K31/198; A61P9/10; A61P25/16

CN108484431A	2018-09-04
CN102405079A	2012-04-04

DATABASE REGISTRY 21 May 2014 (2014-05-21), ANONYMOUS: "Phenylalanine, 4-fluoro-N-[1-oxo-3-[4-(trifluoromethyl)phenyl]-2-propen-1- yl]- (CA INDEX NAME)", XP055853295, retrieved from STN Database accession no. 1607622-41-2
LIN JUN, HU XIAOLONG, LI JUNYAN, LU XIANYU, WANG HAO: "Research Progress in N-Phenylpropenoyl-L-amino Acids", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 42, no. 1, 31 January 2018 (2018-01-31), CN, pages 52 - 59, XP055853270, ISSN: 1001-5094

NANJING TIANHUA PATENT AGENT CO., LTD. (CN)

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