Title:
CO-DRUG-LOADED CELL MICROPARTICLE FORMULATION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/178810
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of drug-targeting carriers. Disclosed are a co-drug-loaded cell microparticle formulation and a preparation method therefor. The co-drug-loaded cell microparticle formulation comprises a microparticle secreted by a tumor cell and a photosensitizer and a tumor-related fibroblast deactivator, which are entrapped together in the microparticle. By means of improving the detail composition and structure of the formulation, taking the microparticle secreted by the tumor cell as a carrier, and entrapping the photosensitizer and the tumor-related fibroblast deactivator in the microparticle at the same time, a co-drug-loaded cell microparticle formulation is obtained. In one aspect, the obtained co-drug-loaded cell microparticle formulation modifies the tumor matrix microenvironment, enhances the enrichment of the photosensitizer in the tumor, and improves the direct killing effect of photothermal therapy on the tumor cell. In another aspect, the obtained co-drug-loaded cell microparticle formulation can also enhance the tumor immunogenicity death caused by the photothermal therapy, promote CD8+ T cell infiltration, reduce antigen-dependent activation-induced CD8+ T cell death caused by the tumor-related fibroblast, and improve the tumor immune microenvironment.
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Inventors:
GAN LU (CN)
YONG TUYING (CN)
LI XIN (CN)
YANG XIANGLIANG (CN)
YONG TUYING (CN)
LI XIN (CN)
YANG XIANGLIANG (CN)
Application Number:
PCT/CN2022/092593
Publication Date:
September 28, 2023
Filing Date:
May 13, 2022
Export Citation:
Assignee:
UNIV HUAZHONG SCIENCE TECH (CN)
International Classes:
A61K9/50; A61K31/593; A61K41/00; A61K45/06; A61K47/46; A61P35/00
Foreign References:
| CN108042805A | 2018-05-18 | |||
| CN113209026A | 2021-08-06 | |||
| CN108543074A | 2018-09-18 |
Other References:
GE LIHONG, LIU ZHICHAO, TIAN YANG: "A novel two-photon ratiometric fluorescent probe for imaging and sensing of BACE1 in different regions of AD mouse brain", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 11, no. 8, 26 February 2020 (2020-02-26), United Kingdom , pages 2215 - 2224, XP093092090, ISSN: 2041-6520, DOI: 10.1039/C9SC05256A
CUI JIEJIE, GONG MENGJIA, HE YUN, LI QILIN, HE TONGCHUAN, BI YANG: "All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 48, no. 1, 1 January 2016 (2016-01-01), GR , pages 349 - 357, XP093092101, ISSN: 1019-6439, DOI: 10.3892/ijo.2015.3235
CUI JIEJIE, GONG MENGJIA, HE YUN, LI QILIN, HE TONGCHUAN, BI YANG: "All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 48, no. 1, 1 January 2016 (2016-01-01), GR , pages 349 - 357, XP093092101, ISSN: 1019-6439, DOI: 10.3892/ijo.2015.3235
Attorney, Agent or Firm:
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY PATENT AGENCY CENTER (CN)
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