Title:
COMPOSITION CONTAINING ARIPIPRAZOLE AS ACTIVE INGREDIENT FOR ENHANCING ANTICANCER EFFECT OF RAF INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/219410
Kind Code:
A1
Abstract:
The present invention pertains to a composition, containing aripiprazole as an active ingredient, for enhancing the anticancer effect of a RAF inhibitor. More specifically, the present invention pertains to a composition for enhancing the anticancer effect of the RAF inhibitor, wherein the composition can treat cancer by acting as an agent for enhancing the anticancer effect of the RAF inhibitor when used in combination therapy with aripiprazole. Administering an effective amount of aripiprazole according to the present invention in combination with the RAF inhibitor is highly effective in enhancing the anticancer effect of the RAF inhibitor, such as by inducing cancer cell death, and thus the composition can be advantageously used as an agent for enhancing the anticancer effect of the RAF inhibitor.
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Inventors:
LIM YOUNG BIN (KR)
LEE HAE JUNE (KR)
KIM KWANG SEOK (KR)
LEE SOO HO (KR)
LEE HAE JUNE (KR)
KIM KWANG SEOK (KR)
LEE SOO HO (KR)
Application Number:
PCT/KR2023/006332
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
A61K31/496; A23L33/10; A61K31/519; A61K45/06; A61P35/00; A61P35/04
Foreign References:
| KR20220036878A | 2022-03-23 | |||
| KR20200111386A | 2020-09-29 | |||
| KR20170026115A | 2017-03-08 |
Other References:
KIM JI YEONG, TAE IN HWAN, LEE BYUNG-MU, KIM HYUNG SIK, YOON SUNGPIL: "Low Doses of the Anti-psychotic Drug Aripiprazole Have Strong P-gp-inhibitory Activity and Sensitize Anti-mitotic Drug-resistant Cancer Cells", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 38, no. 9, 1 September 2018 (2018-09-01), GR , pages 5101 - 5108, XP093106855, ISSN: 0250-7005, DOI: 10.21873/anticanres.12830
SHUHEI SUZUKI, MASASHI OKADA, KENTA KURAMOTO, HIROYUKI TAKEDA, HIROTSUGU SAKAKI, HIKARU WATARAI, TOMOMI SANOMACHI, SHIZUKA SEINO, : "Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 36, no. 10, 12 October 2016 (2016-10-12), GR , pages 5153 - 5162, XP055405053, ISSN: 0250-7005, DOI: 10.21873/anticanres.11085
BADRAN ADNAN, TUL-WAHAB ATIA, ZAFAR HUMAIRA, MOHAMMAD NAYAB, IMAD REHAN, ASHFAQ KHAN MARIAM, BAYDOUN ELIAS, CHOUDHARY M. IQBAL: "Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro", PLOS ONE, vol. 15, no. 8, 3 August 2020 (2020-08-03), pages e0235676, XP093106858, DOI: 10.1371/journal.pone.0235676
KIM MI SEON, BYONG CHUL YOO, WOO SEOK YANG, SANG YUN HAN, DEOK JEONG, JUN MIN SONG, KYUNG HEE KIM, ADITHAN ARAVINTHAN, JI HYE KIM: "Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action", ONCOTARGET., vol. 9, no. 5, 1 January 2018 (2018-01-01), pages 5979 - 5992, XP093106860, DOI: 10.18632/oncotarget.23192
SHUHEI SUZUKI, MASASHI OKADA, KENTA KURAMOTO, HIROYUKI TAKEDA, HIROTSUGU SAKAKI, HIKARU WATARAI, TOMOMI SANOMACHI, SHIZUKA SEINO, : "Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 36, no. 10, 12 October 2016 (2016-10-12), GR , pages 5153 - 5162, XP055405053, ISSN: 0250-7005, DOI: 10.21873/anticanres.11085
BADRAN ADNAN, TUL-WAHAB ATIA, ZAFAR HUMAIRA, MOHAMMAD NAYAB, IMAD REHAN, ASHFAQ KHAN MARIAM, BAYDOUN ELIAS, CHOUDHARY M. IQBAL: "Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro", PLOS ONE, vol. 15, no. 8, 3 August 2020 (2020-08-03), pages e0235676, XP093106858, DOI: 10.1371/journal.pone.0235676
KIM MI SEON, BYONG CHUL YOO, WOO SEOK YANG, SANG YUN HAN, DEOK JEONG, JUN MIN SONG, KYUNG HEE KIM, ADITHAN ARAVINTHAN, JI HYE KIM: "Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action", ONCOTARGET., vol. 9, no. 5, 1 January 2018 (2018-01-01), pages 5979 - 5992, XP093106860, DOI: 10.18632/oncotarget.23192
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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