Title:
COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ENDOTOXIN-RELATED DISEASES AND CONDITIONS
Document Type and Number:
WIPO Patent Application WO2004078142
Kind Code:
A3
Abstract:
The invention provides pharmaceutical compositions for preventing and treating endotoxin-related diseases and conditions, as well as methods for making and using such compositions.
Inventors:
MCSHANE JAMES (US)
Application Number:
PCT/US2004/006713
Publication Date:
December 23, 2004
Filing Date:
March 05, 2004
Export Citation:
Assignee:
EISAI CO LTD (JP)
MCSHANE JAMES (US)
MCSHANE JAMES (US)
International Classes:
A61K9/00; A61K31/351; A61K47/10; (IPC1-7): C07D303/22; A61K31/739; A61K31/203; A61K31/70
Domestic Patent References:
| WO1996039411A1 | 1996-12-12 |
Foreign References:
| US6495532B1 | 2002-12-17 | |||
| US6437006B1 | 2002-08-20 | |||
| US20020183399A1 | 2002-12-05 |
Other References:
ROSSIGNOL D P ET AL: "Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue", JOURNAL OF ENDOTOXIN RESEARCH, vol. 8, no. 6, 2002, pages 483 - 488, XP002903538
ZHANG M ET AL: "LPS antagonist E5564 antagonizes heat shock protein (HSP) 60 and 70 elicited innate immune activation - abstract 142", JOURNAL OF ENDOTOXIN RESEARCH, vol. 8, no. 3, July 2002 (2002-07-01), pages 201, XP002903555
KANEKO K ET AL: "Quantitative determination of a potent lipopolysaccharide antagonist, E5564, in rat and dog plasma by high-performance liquid chromatography wih fluorescene detection", JOURNAL OF CHROMATOGRAPHY, vol. 736, no. 1-2, 24 December 1999 (1999-12-24), pages 67 - 75, XP002903539
ZHANG M ET AL: "LPS antagonist E5564 antagonizes heat shock protein (HSP) 60 and 70 elicited innate immune activation - abstract 142", JOURNAL OF ENDOTOXIN RESEARCH, vol. 8, no. 3, July 2002 (2002-07-01), pages 201, XP002903555
KANEKO K ET AL: "Quantitative determination of a potent lipopolysaccharide antagonist, E5564, in rat and dog plasma by high-performance liquid chromatography wih fluorescene detection", JOURNAL OF CHROMATOGRAPHY, vol. 736, no. 1-2, 24 December 1999 (1999-12-24), pages 67 - 75, XP002903539
Download PDF: