Title:
COMPOSITIONS AND METHODS FOR SURROGATE ANTIBODY MODULATION OF AN IMMUNE RESPONSE AND TRANSPORT
Document Type and Number:
WIPO Patent Application WO2003070192
Kind Code:
A9
Abstract:
Methods and compositions for the modulation of an immune response are provided. Compositions comprise a bi-functional surrogate antibody molecule that interacts with a ligand of interest, wherein the bi-functional surrogate antibody further has attached thereto an immunomodulatory agent and/or a transporting agent. The compositions of the invention find use in a method for delivering an immunomodulatory agent to a ligand of interest. Further provided are methods for modulating an immune response in a subject against a ligand of interest. The method comprises administering a therapeutically effective amount of a bi-functional surrogate antibody of the invention. The methods of the invention also find use in improving the clinical outcome of a subject in need of a modulation in the immune response. Methods are further provided for the treatment or prevention of a variety of conditions and/or disorders including cancer, autoimmune diseases, allergies, prions, and various diseases or conditions of bacterial, parasitic, yeast or viral etiology.
Inventors:
FRIEDMAN STEPHEN B (US)
DRUTZ DAVID J (US)
DRUTZ DAVID J (US)
Application Number:
PCT/US2003/005000
Publication Date:
November 20, 2003
Filing Date:
February 19, 2003
Export Citation:
Assignee:
SYNTHERICA CORP (US)
FRIEDMAN STEPHEN B (US)
DRUTZ DAVID J (US)
FRIEDMAN STEPHEN B (US)
DRUTZ DAVID J (US)
International Classes:
C12N15/09; A61K31/739; A61K38/00; A61K39/395; A61K45/00; A61P1/02; A61P1/04; A61P3/10; A61P11/06; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P37/06; A61P37/08; C07K14/52; C07K16/00; C07K16/08; C07K16/12; C07K16/28; C07K16/30; C07K16/42; C07K16/44; C07K16/46; C07K19/00; C12P21/08; (IPC1-7): A61K/
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