RNA interference mediated inhibition of HIV gene expression using short interfering nucleic acid (siNA)

WIPO Patent Application WO2003070193

A3

The present invention concerns methods and reagents useful in modulating human immunodeficiency virus (HIV) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against HIV gene expression and/or activity. The small nucleic acid molecules are useful in the treatment and diagnosis of HIV infection, AIDS, and any other disease or condition that responds to modulation of HIV expression or activity.

MCSWIGGEN JAMES (US)
BEIGELMAN LEONID (US)
MACEJAK DENNIS (US)

PCT/US2003/005190

August 24, 2006

February 20, 2003

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MCSWIGGEN JAMES (US)
SIRNA THERAPEUTICS INC (US)
BEIGELMAN LEONID (US)
MACEJAK DENNIS (US)

A61K45/06; A61K31/7088; A61K31/712; A61K31/713; A61P31/18; C07H21/00; C12N15/11; C12N15/113; A61K38/00; A61K38/00

WO1999032619A1	1999-07-01
WO1999049029A1	1999-09-30
WO2000044914A1	2000-08-03
WO2001036646A1	2001-05-25

DE19925052A1	2000-12-07
US6372427B1	2002-04-16
US6107062A	2000-08-22
CA2359180A1	2000-08-03
US6506559B1	2003-01-14

CARMICHAEL ET AL.: "Silencing viruses with RNA", NATURE, vol. 418, 25 July 2002 (2002-07-25), pages 379 - 380, XP002969153
JACQUE ET AL.: "Modulation of HIV-1 replication by RNA interference", NATURE, vol. 418, 25 July 2002 (2002-07-25), pages 435 - 438, XP002225640
See also references of EP 1572128A4

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