DBC1 REGULATING CELL SENESCENCE AND USE THEREOF - INST OF BASIC MEDICAL SCIENCES AND SCHOOL OF BASIC MEDICINE PEKING UNION MEDICAL COLLEGE AND CHINESE

Title:

DBC1 REGULATING CELL SENESCENCE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/036300

Kind Code:

A1

Abstract:

DBC1 regulating cell senescence and a use thereof. A use of a DBC1 promoter in the preparation of a drug for preventing or treating senescence-related diseases or disorders. A use of ML216 in the preparation of a drug for preventing or treating senescence-related diseases or disorders. A new avenue is provided for preventing or treating senescence-related diseases or disorders.

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Inventors:

LI JUN (CN)

Application Number:

PCT/CN2022/118135

Publication Date:

March 16, 2023

Filing Date:

September 09, 2022

Export Citation:

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Assignee:

INST OF BASIC MEDICAL SCIENCES AND SCHOOL OF BASIC MEDICINE PEKING UNION MEDICAL COLLEGE AND CHINESE (CN)

International Classes:

A61K45/00; A61P11/00; A61P11/06; A61P13/12; C12Q1/02

Domestic Patent References:

WO2017211983A1

2017-12-14

Foreign References:

CN113797338A	2021-12-17
US20090036375A1	2009-02-05

Other References:

DOU JIANMING, EHMED ELPHIRE, WEN-JUAN XIE, SHOU-YI QIAO, YAN-HUA WU: "Research Progress on the Protein Structure and Biological Function of DBC1", CHINESE BULLETIN OF LIFE SCIENCES, vol. 29, no. 2, 28 February 2017 (2017-02-28), pages 122 - 130, XP093046620, ISSN: 1004-0374, DOI: 10.13376/j.cbls/2017015
LI, JUN ET AL.: "A conserved NAD+ binding pocket that regulates protein-protein interactions during aging", SCIENCE, vol. 355, no. 6331, 24 March 2017 (2017-03-24), XP055474350, DOI: 10.1126/science.aad8242
CHINI EDUARDO NUNES, CHINI CLAUDIA C. S., NIN VERONICA, ESCANDE CARLOS: "Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer", CELL DEATH AND DISEASE, vol. 33, no. 4, 1 August 2013 (2013-08-01), XP093046659, ISSN: 0144-8463, DOI: 10.1042/BSR20130062

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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