Title:
DERIVES D'AMINOINDAZOLES COMME INHIBITEURS DE PROTEINE-KINASE
Document Type and Number:
WIPO Patent Application WO2003078403
Kind Code:
A3
Abstract:
The invention relates to novel indazole derivatives having general formula (I): wherein R is O, S or NH; R3 is an alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryl, heterocycle, cycloalkyl, alkenyl, etc. radical; said radicals being optionally substituted with 1 or more substituents; R4, R5, R6 and R7 are selected independently from the following radicals: hydrogen, halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, -O-C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, trifluoromethyl, trifluoromethoxy, alkyl, alcoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, cycloalkyl, alkenyl, etc.; said radicals being optionally substituted with 1 or more substituents.
Inventors:
DUTRUC-ROSSET GILLES (FR)
LESUISSE DOMINIQUE (FR)
ROONEY THOMAS (FR)
HALLEY FRANCK (FR)
LESUISSE DOMINIQUE (FR)
ROONEY THOMAS (FR)
HALLEY FRANCK (FR)
Application Number:
PCT/FR2003/000752
Publication Date:
April 22, 2004
Filing Date:
March 07, 2003
Export Citation:
Assignee:
AVENTIS PHARMA SA (FR)
DUTRUC-ROSSET GILLES (FR)
LESUISSE DOMINIQUE (FR)
ROONEY THOMAS (FR)
HALLEY FRANCK (FR)
DUTRUC-ROSSET GILLES (FR)
LESUISSE DOMINIQUE (FR)
ROONEY THOMAS (FR)
HALLEY FRANCK (FR)
International Classes:
A61K31/416; A61K31/4196; A61K31/4439; A61K31/454; A61K31/497; A61K31/5377; A61K31/541; A61K31/69; A61K31/695; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P15/00; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P35/00; A61P37/00; A61P37/04; C07D231/56; C07D401/04; C07D401/12; C07D405/04; C07D409/04; C07D409/12; C07F7/18; (IPC1-7): C07D231/56; C07D401/04; C07D405/04; C07D409/04; A61K31/416; A61P25/00
Domestic Patent References:
| WO2001085726A1 | 2001-11-15 |
Foreign References:
| US3316207A | 1967-04-25 | |||
| DE2622761A1 | 1976-12-16 | |||
| DE2458965A1 | 1976-06-16 | |||
| US3133081A | 1964-05-12 | |||
| DE1280878B | 1968-10-24 | |||
| FR2111641A2 | 1972-06-09 | |||
| US3720671A | 1973-03-13 |
Other References:
DAIDONE, GIUSEPPE ET AL: "Synthesis, crystallographic studies and biological evaluation of some 2-substituted 3-indazolyl-4(3H)-quinazolinones and 3-indazolyl-4(3H)-benzotriazinones", HETEROCYCLES (1996), 43(11), 2385-2396, XP002221089
RAFFA, DEMETRIO ET AL: "Synthesis and antiproliferative activity of novel 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3- yl)benzotriazin-4(3H)-one derivatives", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) (1999), 332(9), 317-320, XP002221090
KORBONITS, DEZSO ET AL: "Ring transformation of 3-(2-aminoaryl)-1,2,4-oxadiazoles into 3-acylaminoindazoles;extension of the Boulton-Katritzy scheme", J. CHEM. SOC., PERKIN TRANS. 1 (1982), (3), 759-66, XP002221091
VIVONA, NICOLO ET AL: "Mononuclear heterocyclic rearrangements. Part 12. Rearrangement of 1,2,4-oxadiazoles into indazoles", J. HETEROCYCL. CHEM. (1979), 16(4), 783-4, XP002221092
DATABASE CHEMCATS Chemical Abstract Service; XP002221093
RAFFA, DEMETRIO ET AL: "Synthesis and antiproliferative activity of novel 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3- yl)benzotriazin-4(3H)-one derivatives", ARCHIV DER PHARMAZIE (WEINHEIM, GERMANY) (1999), 332(9), 317-320, XP002221090
KORBONITS, DEZSO ET AL: "Ring transformation of 3-(2-aminoaryl)-1,2,4-oxadiazoles into 3-acylaminoindazoles;extension of the Boulton-Katritzy scheme", J. CHEM. SOC., PERKIN TRANS. 1 (1982), (3), 759-66, XP002221091
VIVONA, NICOLO ET AL: "Mononuclear heterocyclic rearrangements. Part 12. Rearrangement of 1,2,4-oxadiazoles into indazoles", J. HETEROCYCL. CHEM. (1979), 16(4), 783-4, XP002221092
DATABASE CHEMCATS Chemical Abstract Service; XP002221093
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