Title:
DI-POLYMER PROTEIN CONJUGATES AND PROCESSES FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO2006095029
Kind Code:
A3
Abstract:
The present invention refers to di-polymer protein conjugates and processes for their preparation. Further, the present invention refers to the use of such di-polymer protein conjugate, especially di-pegylated protein conjugate, for the manufacture of a medicament for the treatment of disorders.
More Like This:
Inventors:
BAVAND MICHAEL (CH)
BLASEY HORST (CH)
LANG DIETMAR (CH)
BLASEY HORST (CH)
LANG DIETMAR (CH)
Application Number:
PCT/EP2006/060671
Publication Date:
November 30, 2006
Filing Date:
March 13, 2006
Export Citation:
Assignee:
SIEGFRIED LTD (CH)
BAVAND MICHAEL (CH)
BLASEY HORST (CH)
LANG DIETMAR (CH)
BAVAND MICHAEL (CH)
BLASEY HORST (CH)
LANG DIETMAR (CH)
International Classes:
C07K14/535; A61K47/48
Domestic Patent References:
| WO2001076640A2 | 2001-10-18 | |||
| WO1998025965A2 | 1998-06-18 | |||
| WO2000021574A2 | 2000-04-20 | |||
| WO2004083242A1 | 2004-09-30 | |||
| WO2001051510A2 | 2001-07-19 | |||
| WO2004028568A1 | 2004-04-08 | |||
| WO1996011953A1 | 1996-04-25 |
Foreign References:
| US20030143596A1 | 2003-07-31 |
Other References:
GRACE MICHAEL J ET AL: "Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 8, 25 February 2005 (2005-02-25), pages 6327 - 6336, XP002391026, ISSN: 0021-9258
LEE K C ET AL: "Preparation and characterization of polyethylene-glycol-modified salmon calcitonins.", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. MAY 1999, vol. 4, no. 2, May 1999 (1999-05-01), pages 269 - 275, XP009069735, ISSN: 1083-7450
BAILON P ET AL: "Polyethylene glycol-conjugated pharmaceutical proteins", PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY 1998 UNITED KINGDOM, vol. 1, no. 8, 1998, pages 352 - 356, XP002354431, ISSN: 1461-5347
ROBERTS M J ET AL: "Chemistry for peptide and protein PEGylation", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 54, no. 4, 17 June 2002 (2002-06-17), pages 459 - 476, XP002293146, ISSN: 0169-409X
CHAMOW S M ET AL: "MODIFICATION OF CD4 IMMUNOADHESIN WITH MONOMETHOXYPOLY(ETHYLENE GLYCOL) ALDEHYDE VIA REDUCTIVE ALKYLATION", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 5, no. 2, 1 March 1994 (1994-03-01), pages 133 - 140, XP000434384, ISSN: 1043-1802
LEE K C ET AL: "Preparation and characterization of polyethylene-glycol-modified salmon calcitonins.", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. MAY 1999, vol. 4, no. 2, May 1999 (1999-05-01), pages 269 - 275, XP009069735, ISSN: 1083-7450
BAILON P ET AL: "Polyethylene glycol-conjugated pharmaceutical proteins", PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY 1998 UNITED KINGDOM, vol. 1, no. 8, 1998, pages 352 - 356, XP002354431, ISSN: 1461-5347
ROBERTS M J ET AL: "Chemistry for peptide and protein PEGylation", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 54, no. 4, 17 June 2002 (2002-06-17), pages 459 - 476, XP002293146, ISSN: 0169-409X
CHAMOW S M ET AL: "MODIFICATION OF CD4 IMMUNOADHESIN WITH MONOMETHOXYPOLY(ETHYLENE GLYCOL) ALDEHYDE VIA REDUCTIVE ALKYLATION", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 5, no. 2, 1 March 1994 (1994-03-01), pages 133 - 140, XP000434384, ISSN: 1043-1802
Download PDF:
Previous Patent: INTERMITTENT DRIVE SYSTEMS
Next Patent: AMUSEMENT MACHINE COMPRISING RANDOM BALL SELECTION
Next Patent: AMUSEMENT MACHINE COMPRISING RANDOM BALL SELECTION