Title:
EXTRACELLULAR VESICLE SECRETION BOOSTER FOR BOOSTING EXTRACELLULAR VESICLE SECRETION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/063284
Kind Code:
A1
Abstract:
Relating to the secretion of extracellular vesicles from cells, provided are a novel secretion booster and a method for boosting the secretion. This extracellular vesicle secretion booster is characterized by containing an ABCA1 inhibitor. This method for boosting extracellular vesicle secretion is characterized by comprising a boosting step for boosting the extracellular vesicle secretion by allowing a subject having cells to coexist with the aforesaid extracellular vesicle secretion booster of the present invention.
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Inventors:
OCHIYA TAKAHIRO (JP)
YAMAMOTO TOMOFUMI (JP)
YAMAMOTO TOMOFUMI (JP)
Application Number:
PCT/JP2022/037768
Publication Date:
April 20, 2023
Filing Date:
October 11, 2022
Export Citation:
Assignee:
THEORIA SCIENCE INC (JP)
International Classes:
A61K31/7052; C12N15/113; A61P43/00; C12N5/0775; C12N5/10
Domestic Patent References:
| WO2013118606A1 | 2013-08-15 | |||
| WO2020204161A1 | 2020-10-08 | |||
| WO2021095842A1 | 2021-05-20 |
Other References:
KIM MYEONG-JOO, LEE YE-JI, YOON YOUNG-SO, KIM MINSUK, CHOI JI HA, KIM HEE-SUN, KANG JIHEE LEE: "Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR-γ expression and activation in macrophages", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 103, no. 5, 30 March 2018 (2018-03-30), GB , pages 885 - 895, XP093058793, ISSN: 0741-5400, DOI: 10.1002/JLB.2A0817-341RR
WATARU ONO: "Lipid metabolism regulation by microRNA and transcription factor interaction", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 87, no. 6, 1 January 2015 (2015-01-01), JP , pages 733 - 735, XP009545082, ISSN: 0037-1017, DOI: 10.14952/SEIKAGAKU.2015.870733
SHEN WEN; LIU JIA; FAN MINJUAN; WANG SHUKUN; ZHANG YANG; WEN LINQIAO; WANG RUILI; WEI WEI; LI NA; ZHANG YOU; ZHAO GUOHOU: "MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: Anin vivoandin vitrostudy", EXPERIMENTAL CELL RESEARCH, vol. 362, no. 2, 5 December 2017 (2017-12-05), AMSTERDAM, NL , pages 370 - 377, XP085332821, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2017.11.038
KRISTINE NOVAK: "Breaking down barriers", NATURE REVIEWS CANCER, 1 December 2002 (2002-12-01), pages 890 - 891, XP093058800, DOI: 10.1038/nrc961
WATARU ONO: "Lipid metabolism regulation by microRNA and transcription factor interaction", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 87, no. 6, 1 January 2015 (2015-01-01), JP , pages 733 - 735, XP009545082, ISSN: 0037-1017, DOI: 10.14952/SEIKAGAKU.2015.870733
SHEN WEN; LIU JIA; FAN MINJUAN; WANG SHUKUN; ZHANG YANG; WEN LINQIAO; WANG RUILI; WEI WEI; LI NA; ZHANG YOU; ZHAO GUOHOU: "MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: Anin vivoandin vitrostudy", EXPERIMENTAL CELL RESEARCH, vol. 362, no. 2, 5 December 2017 (2017-12-05), AMSTERDAM, NL , pages 370 - 377, XP085332821, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2017.11.038
KRISTINE NOVAK: "Breaking down barriers", NATURE REVIEWS CANCER, 1 December 2002 (2002-12-01), pages 890 - 891, XP093058800, DOI: 10.1038/nrc961
Attorney, Agent or Firm:
NAKAYAMA Yumi (JP)
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