Title:
FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2023/138412
Kind Code:
A1
Abstract:
The present disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvate, stereoisomer, or isotopic variant thereof useful as CDK20 inhibitors, pharmaceutical compositions comprising the same, and use thereof in the treatment of CDK20-associated diseases or conditions such as hepatocellular carcinoma (HCC), colorectal cancer, glioblastoma, lung cancer, medulloblastoma, ovarian carcinoma, prostate cancer, renal cell carcinoma, etc.
Inventors:
REN FENG (CN)
DING XIAO (CN)
LIU YINGTAO (CN)
ZHENG MIN (CN)
ZHU WEI (CN)
DING XIAO (CN)
LIU YINGTAO (CN)
ZHENG MIN (CN)
ZHU WEI (CN)
Application Number:
PCT/CN2023/071020
Publication Date:
July 27, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
A61K31/517; C07D401/12; A61P35/00; C07D239/84; C07D401/04; C07D401/14; C07D403/10; C07D403/14; C07D417/14
Domestic Patent References:
| WO2008020203A1 | 2008-02-21 | |||
| WO2006039718A2 | 2006-04-13 | |||
| WO2008068507A2 | 2008-06-12 |
Foreign References:
| CN102123991A | 2011-07-13 | |||
| CN101652352A | 2010-02-17 | |||
| CN101454294A | 2009-06-10 | |||
| US20100216791A1 | 2010-08-26 |
Other References:
DATABASE Registry 26 August 2021 (2021-08-26), ANONYMOUS: "L22: 2-Quinazolinamine, 6-bromo-N-[1-(l-methyl-4-piperidinyl)-lH-pyrazol-4-yl]", XP009548007, Database accession no. RN 2682115-60-0
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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