Title:
FUSED RING COMPOUND USED AS KETOHEXOKINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/217734
Kind Code:
A1
Abstract:
A compound or a pharmaceutically acceptable salt thereof or a stereoisomer or isotope labeled compound thereof. The compound has a good inhibition effect on ketohexokinase. Provided are a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof or the stereoisomer or isotope labeled compound thereof, and an application of the compound or the pharmaceutically acceptable salt thereof or the stereoisomer or isotope labeled compound thereof in preparation of drugs for treating diseases such as T1D, T2D, LADA, EOD, YOAD, MODY, malnutrition-related diabetes and gestational diabetes.
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Inventors:
WANG JIANHUA (AU)
WANG TINGCHUN (CN)
TANG CHANGHUA (CN)
DENG JIANYANG (CN)
XU XIAOFEI (CN)
WANG TINGCHUN (CN)
TANG CHANGHUA (CN)
DENG JIANYANG (CN)
XU XIAOFEI (CN)
Application Number:
PCT/CN2020/090463
Publication Date:
November 04, 2021
Filing Date:
May 15, 2020
Export Citation:
Assignee:
GUANGZHOU BOJI MEDICAL & BIOTECHNOLOGICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P25/02; A61P25/30; A61P35/00; A61P37/00; C07D403/04; C07D403/14
Domestic Patent References:
| WO2020067735A1 | 2020-04-02 | |||
| WO2020051058A1 | 2020-03-12 |
Foreign References:
| CN108473469A | 2018-08-31 | |||
| CN107074867A | 2017-08-18 | |||
| CN102939283A | 2013-02-20 |
Other References:
FENSOME, A. ET AL.: "Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl) pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, no. 10, 31 March 2020 (2020-03-31), XP086135504, DOI: 10.1016/j.bmc.2020.115481
Attorney, Agent or Firm:
HANGZHOU HUAZHI PATENT OFFICE (GENERAL PARTNERSHIP) (CN)
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