GLYCOPEPTIDE ANTIBIOTIC DERIVATIVE

WIPO Patent Application WO/2007/138999

A1

It is intended to provide a novel glycopeptide antibiotic derivative. A compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. In the formula (I), RA represents -X1-Ar1-X2-Y-X3-Ar2 (X1, X2, X3 represent a single bond, a heteroatom group selected from -N=, =N-, -NR1- (R1 represents H or lower alkyl), -O-, -S-, -SO-, and -SO2- or a linking group thereof, or alkylene or alkenylene which may be interrupted or substituted by one or more of such heteroatom groups; Y represents -NR2CO-, -CONR2- (R2 represents H or lower alkyl) or a group represented by the formula (II) (R3 represents alkylene); Ar1 and Ar2 represent a carbocyclic group or heterocyclic group which may be substituted and have an unsaturated bond; RB represents -NHNRXRY or -NRZORW (RX represents hydrogen or lower alkyl, RY represents hydrogen or lower alkyl which may be substituted, C(=NH)NH2, CSNH2, COCONH2, CN, a heterocyclic group which may be substituted or carbamoyl which may be substituted; RZ represents hydrogen or lower alkyl; RW represents hydrogen, lower alkyl which may be substituted, lower alkenyl which may be substituted, a heterocyclic group which may be substituted, heterocyclic carbonyl which may be substituted or carbamoyl which may be substituted); RC represents hydrogen or alkyl which may be substituted (the alkyl may be interrupted by a heteroatom group selected from N=, =N-, -NR1- (R1 represents H or lower alkyl), -O-, -S-, -SO-, and -SO2-); R represents alkyl which may be substituted.

JPS6431799	PEPTIDE AND ITS PREPARATION
WO/1998/051703	20(S) CAMPTOTHECIN GLYCOCONJUGATES,
WO/1996/028462	17-DIFLUOROMETHYLENE-OESTRATRIENES

NISHITANI YASUHIRO (JP)
YOSHIDA OSAMU (JP)
IWAKI TSUTOMU (JP)
KATO ISSEI (JP)

PCT/JP2007/060673

December 06, 2007

May 25, 2007

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SHIONOGI & CO (JP)
NISHITANI YASUHIRO (JP)
YOSHIDA OSAMU (JP)
IWAKI TSUTOMU (JP)
KATO ISSEI (JP)

C07K9/00; A61K38/00; A61P31/04; C07K7/06; C07K14/36

WO2005018743A1	2005-03-03
WO2006057303A1	2006-06-01
WO2006057288A1	2006-06-01
WO1996030401A1	1996-10-03
WO2004044222A2	2004-05-27
WO2001081372A2	2001-11-01
WO2006057303A1	2006-06-01
WO2000039156A1	2000-07-06

JP2005505542A	2005-02-24
JPS61251699A	1986-11-08
JPH07258289A	1995-10-09
JP2000302687A	2000-10-31
JP2001163898A	2001-06-19

BARRETT J.F. ET AL.: "Recent developments in glycopeptides antibacterials", CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 6, no. 8, 2005, pages 781 - 790, XP003019608
REYES N. ET AL.: "Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resitant Staphylococcus aureus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 49, no. 10, 2005, pages 4344 - 4346, XP003019609
PACE J.L. ET AL.: "Glycopeptides: Update on an old successful antibiotic class", BIOCHEMICAL PHARMACOLOGY, vol. 71, no. 7, March 2006 (2006-03-01), pages 968 - 980, XP005318689
See also references of EP 2030982A4
EXPERT OPIN. THER. PATENTS, vol. 14, 2004, pages 141 - 173

TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome, Chuo-ku,Osaka-sh, Osaka 01, JP)

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