Title:
HETEROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/153414
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a heterocyclic compound that can have an antagonist activity against an NMDA receptor including an NR2B subunit and is thus expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia, etc. Provided are a compound represented by formula (I) or a salt thereof: [where, each symbol is as described in the specification.]
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Inventors:
OGURO YUYA (JP)
KAMATA MAKOTO (JP)
MIKAMI SATOSHI (JP)
MORIMOTO SHINJI (JP)
TAKASHIMA SACHIE (JP)
DAINI MASAKI (JP)
KUBO OSAMU (JP)
KIKUCHI FUMIAKI (JP)
TOITA AKINORI (JP)
PUENNER FLORIAN (JP)
KASAHARA TAKAHITO (JP)
MURAKAMI MASATAKA (JP)
IKEDA SHUHEI (JP)
YAMAGUCHI FUMIE (JP)
NAKAMURA MINORU (JP)
YUKAWA TAKAFUMI (JP)
KAMATA MAKOTO (JP)
MIKAMI SATOSHI (JP)
MORIMOTO SHINJI (JP)
TAKASHIMA SACHIE (JP)
DAINI MASAKI (JP)
KUBO OSAMU (JP)
KIKUCHI FUMIAKI (JP)
TOITA AKINORI (JP)
PUENNER FLORIAN (JP)
KASAHARA TAKAHITO (JP)
MURAKAMI MASATAKA (JP)
IKEDA SHUHEI (JP)
YAMAGUCHI FUMIE (JP)
NAKAMURA MINORU (JP)
YUKAWA TAKAFUMI (JP)
Application Number:
PCT/JP2020/002216
Publication Date:
July 30, 2020
Filing Date:
January 23, 2020
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61P25/04; A61K31/277; A61K31/44; A61K31/4436; A61K31/444; A61P25/06; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07C255/60; C07D213/82; C07D213/85; C07D409/12
Domestic Patent References:
| WO2017174158A1 | 2017-10-12 | |||
| WO2017027343A1 | 2017-02-16 | |||
| WO2017027345A1 | 2017-02-16 | |||
| WO2012158691A1 | 2012-11-22 | |||
| WO2008111299A1 | 2008-09-18 | |||
| WO2002081428A1 | 2002-10-17 | |||
| WO2002080899A1 | 2002-10-17 | |||
| WO2002072558A1 | 2002-09-19 | |||
| WO2001025181A1 | 2001-04-12 | |||
| WO2014172044A1 | 2014-10-23 | |||
| WO2016104434A1 | 2016-06-30 | |||
| WO2001000663A2 | 2001-01-04 |
Foreign References:
| JP2009528992A | 2009-08-13 | |||
| US20020151534A1 | 2002-10-17 | |||
| JPH11514333A | 1999-12-07 | |||
| JP2001500852A | 2001-01-23 | |||
| JP2019010536A | 2019-01-24 |
Other References:
TAYLOR, STEVEN J. ET AL.: "Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 5864 - 5868, XP026640588, DOI: 10.1016/j.bmcl.2009.08.074
DATABASE CAS [online] 25 November 2012 (2012-11-25), "Benzamide, N-[(4-cyano-2- fluorophenyl)methyl]-4-methoxy-( CA INDEX NAME", retrieved from STN Database accession no. 1406153-87-4
DATABASE CAS [online] 6 December 2011 (2011-12-06), "3-Pyridinecarboxamide, N-[(2- chloro-4-cyanophenyl)methyl]-6-(3,3,3- trifluoropropoxy)-( CA INDEX NAME", retrieved from STN Database accession no. 1349423-75-1
NEURON, vol. 12, 1994, pages 529 - 540
J. COMP. NEUROL., vol. 338, 1993, pages 377 - 390
MOL. CELLS, vol. 7, 1997, pages 64 - 71
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
THER. ADV. PSYCHOPHARMACOL., vol. 4, 2014, pages 75 - 99
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (J. CLIN. PSYCHOPHARMACOL., vol. 28, 2008, pages 631 - 637
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (J. PHARMACOL. EXP. THER., vol. 321, 2007, pages 564 - 572
EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 32, 2010, pages 798 - 810
PAIN, vol. 153, 2012, pages 1022 - 1029
ANNALS OF PHARMACOTHERAPY, vol. 42, 2007, pages 32 - 38
JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 337, 2014, pages 162 - 166
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
"Their Mechanism and Essence (Hideo Togo, Kodansha", REV. ORGANIC NAME REACTIONS, vol. 14-15
JIE JACK LI: "Modern Organic Synthesis in the Laboratory", vol. I - VII, JOHN WILEY & SONS INC, article "A Collection of Standard Experimental Procedures"
THEODORA W. GREENEPETER G. M. WUTS: "Strategic Applications of Named Reactions in Organic Synthesis", vol. 1-14, 2007, VCH PUBLISHERS INC.
P. J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
See also references of EP 3915638A4
DATABASE CAS [online] 25 November 2012 (2012-11-25), "Benzamide, N-[(4-cyano-2- fluorophenyl)methyl]-4-methoxy-( CA INDEX NAME", retrieved from STN Database accession no. 1406153-87-4
DATABASE CAS [online] 6 December 2011 (2011-12-06), "3-Pyridinecarboxamide, N-[(2- chloro-4-cyanophenyl)methyl]-6-(3,3,3- trifluoropropoxy)-( CA INDEX NAME", retrieved from STN Database accession no. 1349423-75-1
NEURON, vol. 12, 1994, pages 529 - 540
J. COMP. NEUROL., vol. 338, 1993, pages 377 - 390
MOL. CELLS, vol. 7, 1997, pages 64 - 71
"Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "IYAKUHIN no KAIHATSU (Development of Pharmaceuticals", pages: 163 - 198
THER. ADV. PSYCHOPHARMACOL., vol. 4, 2014, pages 75 - 99
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (J. CLIN. PSYCHOPHARMACOL., vol. 28, 2008, pages 631 - 637
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (J. PHARMACOL. EXP. THER., vol. 321, 2007, pages 564 - 572
EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 32, 2010, pages 798 - 810
PAIN, vol. 153, 2012, pages 1022 - 1029
ANNALS OF PHARMACOTHERAPY, vol. 42, 2007, pages 32 - 38
JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 337, 2014, pages 162 - 166
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
"Their Mechanism and Essence (Hideo Togo, Kodansha", REV. ORGANIC NAME REACTIONS, vol. 14-15
JIE JACK LI: "Modern Organic Synthesis in the Laboratory", vol. I - VII, JOHN WILEY & SONS INC, article "A Collection of Standard Experimental Procedures"
THEODORA W. GREENEPETER G. M. WUTS: "Strategic Applications of Named Reactions in Organic Synthesis", vol. 1-14, 2007, VCH PUBLISHERS INC.
P. J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
See also references of EP 3915638A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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