Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/050409
Kind Code:
A1
Abstract:
Provided is a novel heterocyclic compound having an aryl hydrocarbon receptor antagonist activity and useful for the promotion of platelet production, the compound being represented by the general formula [I]: wherein ring A, ring B, R1, R2, R3, R4, n, and X are as defined above, or a salt thereof.
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Inventors:
OHDACHI KAZUHIRO (JP)
FUJIMORI YUSUKE (JP)
MAKITA NAOYA (JP)
KOSEKI NORITAKA (JP)
HAYASHI HIDEKI (JP)
SAKAMOTO YUKI (JP)
MINENO KURUMI (JP)
TAGA RYOSUKE (JP)
FUJIMORI YUSUKE (JP)
MAKITA NAOYA (JP)
KOSEKI NORITAKA (JP)
HAYASHI HIDEKI (JP)
SAKAMOTO YUKI (JP)
MINENO KURUMI (JP)
TAGA RYOSUKE (JP)
Application Number:
PCT/JP2019/035233
Publication Date:
March 12, 2020
Filing Date:
September 06, 2019
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C07D498/14; A61K31/519; A61P7/04; C07D513/14
Domestic Patent References:
| WO2014138485A1 | 2014-09-12 | |||
| WO2012082997A1 | 2012-06-21 | |||
| WO2018195397A2 | 2018-10-25 | |||
| WO2014138485A1 | 2014-09-12 | |||
| WO2016204256A1 | 2016-12-22 | |||
| WO2010059401A2 | 2010-05-27 |
Other References:
K. J. SMITH ET AL: "Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 338, no. 1, 1 July 2011 (2011-07-01), pages 318 - 327, XP055122740, ISSN: 0022-3565, DOI: 10.1124/jpet.110.178392
IMAN FARES ET AL: "Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal", SCIENCE (NEW YORK, N.Y.), vol. 345, no. 6203, 19 September 2014 (2014-09-19), United States, pages 1509 - 1512, XP055370388
TAKAYAMA ET AL., BLOOD, vol. 111, 2008, pages 5298
BOITANO ET AL., SCIENCE, vol. 329, 2010, pages 1345
STRASSEL ET AL., BLOOD, vol. 127, 2016, pages 2231
ITO ET AL., CELL, vol. 174, 2018, pages 636
WALDEMAR ADAMRAINER T. FELLCHANTU R. SAHA-MOLLERCONG-GUI ZHAO, TETRAHEDRON: ASYMMETRY, September 1998 (1998-09-01), pages 397 - 401
YUANMING ZHUYONG TUHONGWU YUYIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
GARRION PM ET AL., FUNDAM APPL TOXICOL, vol. 30, 1996, pages 194
IMAN FARES ET AL: "Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal", SCIENCE (NEW YORK, N.Y.), vol. 345, no. 6203, 19 September 2014 (2014-09-19), United States, pages 1509 - 1512, XP055370388
TAKAYAMA ET AL., BLOOD, vol. 111, 2008, pages 5298
BOITANO ET AL., SCIENCE, vol. 329, 2010, pages 1345
STRASSEL ET AL., BLOOD, vol. 127, 2016, pages 2231
ITO ET AL., CELL, vol. 174, 2018, pages 636
WALDEMAR ADAMRAINER T. FELLCHANTU R. SAHA-MOLLERCONG-GUI ZHAO, TETRAHEDRON: ASYMMETRY, September 1998 (1998-09-01), pages 397 - 401
YUANMING ZHUYONG TUHONGWU YUYIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
GARRION PM ET AL., FUNDAM APPL TOXICOL, vol. 30, 1996, pages 194
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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