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Title:
HYALURONIC ACID/METHOTREXATE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/085294
Kind Code:
A1
Abstract:
A hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases. The hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases comprises hyaluronic acid and methotrexate bonded to a carboxy group of the acid through a linker having a peptide chain comprising one to eight amino acids.

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Inventors:
IKEYA HITOSHI (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
Application Number:
PCT/JP2005/003739
Publication Date:
September 15, 2005
Filing Date:
March 04, 2005
Export Citation:
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Assignee:
DENKI KAGAKU KOGYO KK (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
IKEYA HITOSHI (JP)
MORIKAWA TADASHI (JP)
TAKAHASHI KOICHI (JP)
TAMURA TATSUYA (JP)
OKAMACHI AKIRA (JP)
ISHIZAWA TAKENORI (JP)
SATO HARUHIKO (JP)
HIGUCHI YOSHINOBU (JP)
International Classes:
A61K31/519; A61K47/48; A61P19/02; C07K9/00; C08B37/08; C07D475/10; C07K5/00; (IPC1-7): C08B37/08; A61K31/519; A61K47/48; A61P19/02
Domestic Patent References:
WO1994019376A11994-09-01
WO1994019376A11994-09-01
WO1999059603A11999-11-25
WO2002044218A12002-06-06
WO2001068105A12001-09-20
WO1992011037A21992-07-09
WO2000064486A22000-11-02
WO1994013327A11994-06-23
Foreign References:
JP2002542304A2002-12-10
JPH08507750A1996-08-20
JPH11222425A1999-08-17
JPH09188705A1997-07-22
JPH0680705A1994-03-22
JPH0885703A1996-04-02
JPS6440499A1989-02-10
JPH0539306A1993-02-19
US5902795A1999-05-11
US4489065A1984-12-18
US6322815B12001-11-27
Other References:
ROSOWSKY A. ET AL: "Methotrexate Analogs. 23. Synthesis, Dihydrofolate Reductase Affinity, Cytotoxicity, and in Vivo Antitumor Activity of Some putative Degradation Products of Methotrexate-poly (L lysine) Conjugates.", JOURNAL OF MEDICINE CHEMISTRY., vol. 27, no. 7, 1984, pages 888 - 893, XP002989867
LUO Y ET AL., BIOMACROMOLECULES, vol. 1, no. 2, 2000, pages 208 - 218
OUCHI T ET AL., ACS SYMPOSIUM SERIES, vol. 469, 1991
Attorney, Agent or Firm:
Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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