Title:
INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO2005014530
Kind Code:
A3
Abstract:
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.
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Inventors:
SALTER-CID LUISA MARIA (US)
WANG ERIC YANJUN (US)
COCKERILL KEITH (US)
LINNIK MATTHEW D (US)
VICTORIA EDWARD J (US)
WANG ERIC YANJUN (US)
COCKERILL KEITH (US)
LINNIK MATTHEW D (US)
VICTORIA EDWARD J (US)
Application Number:
PCT/US2004/025699
Publication Date:
July 07, 2005
Filing Date:
August 06, 2004
Export Citation:
Assignee:
JOLLA PHARMA (US)
SALTER-CID LUISA MARIA (US)
WANG ERIC YANJUN (US)
COCKERILL KEITH (US)
LINNIK MATTHEW D (US)
VICTORIA EDWARD J (US)
SALTER-CID LUISA MARIA (US)
WANG ERIC YANJUN (US)
COCKERILL KEITH (US)
LINNIK MATTHEW D (US)
VICTORIA EDWARD J (US)
International Classes:
C07C211/26; C07C211/27; C07C239/20; C07C243/18; (IPC1-7): C07C243/18; A61K31/15; C07C239/08; C07C243/16
Foreign References:
| DE2739380A1 | 1979-03-08 |
Other References:
LYLES, G. A.: "Mammalian Plasma and Tissue-bound Semicarbazide-senssitive Amine Oxidases: Biochemical, Pharmacological and Toxicological Aspects", INT. J. BIOCHEM. CELL. BIOL., vol. 28, no. 3, 1996, pages 259 - 274, XP002314560
DANIIL D ET AL: "PHOTOLYSE VON 2-OXO-2,5-DIHYDRO-1,3,4-OXADIAZOLEN IN GEGENWART VON OLEFINEN", September 1977, TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, PAGE(S) 3155-3158, ISSN: 0040-4039, XP002072098
CRICCHIO R ET AL: "OXIMES OF 3-FORMYLRIFAMYCIN SV.SYNTHESIS, ANTIBACTERIAL ACTIVITY, AND OTHER BIOLOGICAL PROPERTIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 17, 1974, pages 396 - 403, XP001000166, ISSN: 0022-2623
JOHNSON, G.; BOXER, P. A.; DRUMMOND, J. T.; BOYD, D. K.; ANDERSON, R. J.: "Identification and Evaluation of A-Alkyl Substituted Hydroxamic Acids as Potent in vitro Inhibitors of the Hepatic Glycine Cleavage System and Investigation of Their Action on in vivo Central Nervous System Glycine Concentration.", ARZNEIM. FORSCH, vol. 39, no. 4, 1989, pages 432 - 437, XP001204823
WOLLF, H. P.; KÜHNLE, H. F.: "Synthesis and Hypoglycemic Activity of N-alkylated Hydrazonopropionic Acids", J. MED. CHEM., vol. 28, 1985, pages 1436 - 1440, XP002314561
BANERT, K.; HAGEDORN, M.: "Synthesis and Diels-alder Reactions of 2-Alkylazo-Substituted 1,3-Butadienes", TETRAHEDRON LETTERS, vol. 33, no. 48, 1992, pages 7331 - 7334, XP002314562
CRAWFORD, R. J.; TAKAGI, K.: "Mechanism of Azoalkane Thermolysis. Concerted or Nonconcerted?", J. AM. CHEM. SOC, 1972, pages 7406 - 7416, XP002314563
DANIIL D ET AL: "PHOTOLYSE VON 2-OXO-2,5-DIHYDRO-1,3,4-OXADIAZOLEN IN GEGENWART VON OLEFINEN", September 1977, TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, PAGE(S) 3155-3158, ISSN: 0040-4039, XP002072098
CRICCHIO R ET AL: "OXIMES OF 3-FORMYLRIFAMYCIN SV.SYNTHESIS, ANTIBACTERIAL ACTIVITY, AND OTHER BIOLOGICAL PROPERTIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 17, 1974, pages 396 - 403, XP001000166, ISSN: 0022-2623
JOHNSON, G.; BOXER, P. A.; DRUMMOND, J. T.; BOYD, D. K.; ANDERSON, R. J.: "Identification and Evaluation of A-Alkyl Substituted Hydroxamic Acids as Potent in vitro Inhibitors of the Hepatic Glycine Cleavage System and Investigation of Their Action on in vivo Central Nervous System Glycine Concentration.", ARZNEIM. FORSCH, vol. 39, no. 4, 1989, pages 432 - 437, XP001204823
WOLLF, H. P.; KÜHNLE, H. F.: "Synthesis and Hypoglycemic Activity of N-alkylated Hydrazonopropionic Acids", J. MED. CHEM., vol. 28, 1985, pages 1436 - 1440, XP002314561
BANERT, K.; HAGEDORN, M.: "Synthesis and Diels-alder Reactions of 2-Alkylazo-Substituted 1,3-Butadienes", TETRAHEDRON LETTERS, vol. 33, no. 48, 1992, pages 7331 - 7334, XP002314562
CRAWFORD, R. J.; TAKAGI, K.: "Mechanism of Azoalkane Thermolysis. Concerted or Nonconcerted?", J. AM. CHEM. SOC, 1972, pages 7406 - 7416, XP002314563
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