Title:
METHOD FOR EXTRACTING PLANT-DERIVED EXOSOME, EXOSOME ISOLATED THEREBY, AND COSMETIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/085419
Kind Code:
A1
Abstract:
The present disclosure provides: a method for separating an exosome whereby the separation efficiency of an exosome can be increased and an exosome having high stability can be obtained; and a cosmetic material composition including an exosome having improved wrinkle amelioration, cell growth, and anti-inflammatory or anti-aging effects. Disclosed is a method for extracting a plant-derived exosome, the method comprising: (a) a step for washing and squeezing a plant to obtain a plant juice; (b) a first centrifugation step for centrifuging the plant juice to obtain a first supernatant; (c) a second centrifugation step for centrifuging the first supernatant to obtain a second supernatant; (d) a step for subjecting the secondary supernatant to tangential flow filtration (TFF) to obtain a separated product; and (e) a step for adding beads to which an antibody is attached to the separated product to obtain a plant-derived exosome extract. Also disclosed a cosmetic material composition comprising 0.1 to 20 wt% of a plant-derived exosome with respect to the total weight of the composition
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Inventors:
JEON JU HEE (KR)
KIM YOON AH (KR)
CHO SE HEE (KR)
JUNG SUNG WON (KR)
CHO YOUN KI (KR)
JUNG HYO IL (KR)
PARK SUN YOUNG (KR)
JEONG HYO RIM (KR)
YU JIAN NING (KR)
KIM YOON AH (KR)
CHO SE HEE (KR)
JUNG SUNG WON (KR)
CHO YOUN KI (KR)
JUNG HYO IL (KR)
PARK SUN YOUNG (KR)
JEONG HYO RIM (KR)
YU JIAN NING (KR)
Application Number:
PCT/KR2023/012746
Publication Date:
April 25, 2024
Filing Date:
August 29, 2023
Export Citation:
Assignee:
ACTIVON CO LTD (KR)
THE DABOM CORP (KR)
THE DABOM CORP (KR)
International Classes:
A61K8/9789; A61Q19/00; A61Q19/08
Domestic Patent References:
| WO2019088656A1 | 2019-05-09 |
Foreign References:
| KR102125567B1 | 2020-06-22 | |||
| KR102265811B1 | 2021-06-16 |
Other References:
YURY SHKRYL: "Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine", APPLIED SCIENCES, MDPI SWITZERLAND, vol. 12, no. 16, 18 August 2022 (2022-08-18), pages 8262, XP093157267, ISSN: 2076-3417, DOI: 10.3390/app12168262
NGOC PHUNG LY: "Plant-derived nanovesicles: Current understanding and applications for cancer therapy", BIOACTIVE MATERIALS, vol. 22, 1 April 2023 (2023-04-01), pages 365 - 383, XP093162495, ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2022.10.005
NGOC PHUNG LY: "Plant-derived nanovesicles: Current understanding and applications for cancer therapy", BIOACTIVE MATERIALS, vol. 22, 1 April 2023 (2023-04-01), pages 365 - 383, XP093162495, ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2022.10.005
Attorney, Agent or Firm:
KIM, Jin Dong (KR)
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