METHOD AND IDENTIFICATION OF DOWNSTREAM MRNA LIGANDS TO FMRP AND THEIR ROLE IN FRAGILE X SYNDROME AND ASSOCIATED DISORDERS

Title:

METHOD AND IDENTIFICATION OF DOWNSTREAM MRNA LIGANDS TO FMRP AND THEIR ROLE IN FRAGILE X SYNDROME AND ASSOCIATED DISORDERS

Document Type and Number:

WIPO Patent Application WO2003041659

Kind Code:

A3

Abstract:

Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.

More Like This:

JP6420273	Engineering of systems, methods and optimization guide compositions for sequence manipulation
WO/2006/030737	CONSTRUCTION OF ARTERIAL OCCLUSIVE DISEASE ANIMAL MODEL
WO/2000/039294	PORCINE CELLS INCAPABLE OF EXPRESSING CD40 ANTIGEN, FOR XENOTRANSPLANTATION

Inventors:

WARREN STEPHEN T (US)
BROWN-KENNERLY VICTORIA (US)
JIN PENG (US)
CEMAN STEPHANIE (US)
DARNELL ROBERT B (US)
DARNELL JENNIFER C (US)
KEENE JACK D (US)
TENENBAUM SCOTT A (US)

Application Number:

PCT/US2002/036861

Publication Date:

July 31, 2003

Filing Date:

November 15, 2002

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV EMORY (US)
UNIV DUKE (US)
UNIV ROCKEFELLER (US)
WARREN STEPHEN T (US)
BROWN-KENNERLY VICTORIA (US)
JIN PENG (US)
CEMAN STEPHANIE (US)
DARNELL ROBERT B (US)
DARNELL JENNIFER C (US)
KEENE JACK D (US)
TENENBAUM SCOTT A (US)

International Classes:

A01K67/027; C07H21/04; C07K14/705; C07K16/28; C12Q1/68; (IPC1-7): C12Q1/68; A61K48/00; C07H21/04; C12P19/34

Foreign References:

US5962332A	1999-10-05
US6165719A	2000-12-26

Other References:

DATABASE GENBANK [online] 8 May 2001 (2001-05-08), ZHANG ET AL., XP002964059, accession no. NCBI Database accession no. (AF130092)

Download PDF:

View/Download PDF PDF Help

Previous Patent: PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED-2,3,4,5- TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS

Next Patent: SOLUBILIZED TOPOISOMERASE POISONS