Title:
METHOD FOR PREPARING 3-HYDROXY-3-METHYLBUTANOIC ACID OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/016983
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for preparing a 3-hydroxy-3-methylbutanoic acid or a salt thereof, the method being capable of efficiently preparing a highly pure 3-hydroxy-3-methylbutanoic acid or a salt thereof. According to the method, a highly pure 3-hydroxy-3-methylbutanoic acid or a salt thereof can be prepared by performing at least one operation among (a)-(d) below on a solution which is exposed to an environment of pH 6.0 or lower and contains 3-hydroxy-3-methylbutanoic acid and impurities. (a) Hypochlorous acid or a salt thereof is added to the solution. (b) The solution is kept at 40-200°C for at least 30 minutes (the solution contains hypochlorous acid or a salt thereof). (c) A calcium salt is added to the solution, and precipitated calcium 2,3-dihydroxy-3-methylbutanoate is separated from a liquid phase in which a 3-hydroxy-3-methylbutanoic acid and/or a salt thereof is dissolved. (d) A base is added to the solution, and a liquid phase in which the produced 2,3-dihydroxy-3-methylbutanoate is dissolved is separated from a liquid phase in which a 3-hydroxy-3-methylbutanoic acid and/or a salt thereof is dissolved.
Inventors:
SUGITA NAOKI (JP)
HOSHI TOSHIO (JP)
HOSHI TOSHIO (JP)
Application Number:
PCT/JP2018/002463
Publication Date:
January 24, 2019
Filing Date:
January 26, 2018
Export Citation:
Assignee:
KOBAYASHI PERFUMERY CO LTD (JP)
International Classes:
C07C51/48; C07C51/43; C07C59/01
Foreign References:
| US4992470A | 1991-02-12 | |||
| US6090978A | 2000-07-18 | |||
| JP2014525410A | 2014-09-29 | |||
| JP2016514733A | 2016-05-23 | |||
| JP2014525410A | 2014-09-29 | |||
| JP2016514733A | 2016-05-23 |
Other References:
COFFMAN, D. D. ET AL.: "Syntheses by free-radical reactions. V. A new synthesis of carboxylic acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 80, no. 11, 5 June 1958 (1958-06-05), pages 2882 - 2887, XP055023519
See also references of EP 3656755A4
See also references of EP 3656755A4
Attorney, Agent or Firm:
TANIMIZU Koichi et al. (JP)
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