Title:
METHOD OF PRODUCING BETA OR GAMMA AMINO ACIDS USING GLUTAMIC ACID REGENERATION REACTION
Document Type and Number:
WIPO Patent Application WO/2020/130384
Kind Code:
A1
Abstract:
The present invention relates to a method of producing beta or gamma amino acids using a glutamic acid regeneration reaction. The present invention can induce the production of high concentrations of beta and gamma amino acids by using glutamic acid as an amino donor, and the present invention can increase productivity by removing an inhibitory effect of by-products that may be problematic in a conventional reaction. In addition, the present invention uses a cheaper amino donor, and thus is advantageous in the price competitiveness of a product and also can overcome the inhibitory effect on the product through optimization of reaction conditions.
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Inventors:
CHOI IN SUK (KR)
YUN HYUNG DON (KR)
KIM GEON HEE (KR)
JEON HYUN WOO (KR)
YUN HYUNG DON (KR)
KIM GEON HEE (KR)
JEON HYUN WOO (KR)
Application Number:
PCT/KR2019/016262
Publication Date:
June 25, 2020
Filing Date:
November 25, 2019
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
CKD BIO CORP (KR)
CKD BIO CORP (KR)
International Classes:
C12P13/00; C12P13/04
Foreign References:
| KR20150008305A | 2015-01-22 |
Other References:
SHON, M. ET AL.: "Enzymatic synthesis of chiral y-amino acids using co-transaminase", CHEMICAL COMMUNICATIONS, vol. 50, 2014, pages 12680 - 12683, XP055720609
XUE, Y. -P. ET AL.: "Enzymatic asymmetric synthesis of chiral amino acids", CHEMICAL SOCIETY REVIEWS, vol. 47, no. 4, 2018, pages 1516 - 1561, XP055720621
HONG, E. Y. ET AL.: "Asymmetric synthesis of L-tert-leucine and L-3-hydroxyadamaniylglycine using branched chain aminotransferase", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 66, 2010, pages 228 - 233, XP027145678
KOSZELEWSKI, D. ET AL.: "omega-Transaminases for the synthesis of non-racemic a-chiral primary amines", TRENDS IN BIOTECHNOLOGY, vol. 28, 2010, pages 324 - 332, XP027059911
KIM, G. -H. ET AL.: "Glutamate as an Efficient Amine Donor for the Synthesis of Chiral beta-and gamma-Amino Acids Using Transaminase", CHEMCATCHEM, vol. 11, 31 January 2019 (2019-01-31), pages 1437 - 1440, XP055720622
XUE, Y. -P. ET AL.: "Enzymatic asymmetric synthesis of chiral amino acids", CHEMICAL SOCIETY REVIEWS, vol. 47, no. 4, 2018, pages 1516 - 1561, XP055720621
HONG, E. Y. ET AL.: "Asymmetric synthesis of L-tert-leucine and L-3-hydroxyadamaniylglycine using branched chain aminotransferase", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 66, 2010, pages 228 - 233, XP027145678
KOSZELEWSKI, D. ET AL.: "omega-Transaminases for the synthesis of non-racemic a-chiral primary amines", TRENDS IN BIOTECHNOLOGY, vol. 28, 2010, pages 324 - 332, XP027059911
KIM, G. -H. ET AL.: "Glutamate as an Efficient Amine Donor for the Synthesis of Chiral beta-and gamma-Amino Acids Using Transaminase", CHEMCATCHEM, vol. 11, 31 January 2019 (2019-01-31), pages 1437 - 1440, XP055720622
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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