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Title:
METHOD FOR PRODUCING MATURE DENDRITIC CELLS
Document Type and Number:
WIPO Patent Application WO/2023/245609
Kind Code:
A1
Abstract:
Provided is a method for producing mature dendritic cells from peripheral blood mononuclear cells (PBMCs). The method includes the steps of treating the PBMCs with a cultivating medium supplemented with interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to produce immature dendritic cells; and then treating the immature dendritic cells with the cultivating medium supplemented with IL-4, GM-CSF, tumor necrosis factor alpha (TNF-α), and Prostaglandin E 2 (PGE 2) to produce the mature dendritic cells. The PBMCs used in the method are isolated from a leukocyte concentrate or a cryopreserved peripheral blood stem cells (PBSCs) stock.

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Inventors:
CHIOU TZEON-JYE (CN)
LIU CHUN-YU (CN)
HUANG ZI-HAN (CN)
CHENG YI-PEI (CN)
Application Number:
PCT/CN2022/101069
Publication Date:
December 28, 2023
Filing Date:
June 24, 2022
Export Citation:
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Assignee:
LIHPAO LIFE SCIENCE CORP (CN)
International Classes:
C12N5/0786; C12N5/0784
Domestic Patent References:
WO2013127976A12013-09-06
WO2008098770A12008-08-21
Foreign References:
CN109486763A2019-03-19
CN1543502A2004-11-03
CN109355260A2019-02-19
CN114149970A2022-03-08
CN1561388A2005-01-05
US20090053251A12009-02-26
Other References:
WU XUEJIE, XU FENG, LIU JINLIANG, WANG GUIQIANG: "Comparative study of dendritic cells matured by using IL-1β, IL-6, TNF-α and prostaglandins E2 for different time span", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 14, no. 2, 1 August 2017 (2017-08-01), GR , pages 1389 - 1394, XP093120861, ISSN: 1792-0981, DOI: 10.3892/etm.2017.4649
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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