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Title:
METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2023/182274
Kind Code:
A1
Abstract:
The present invention provides a method for efficiently producing a nucleic acid oligomer, in particular, a method for producing a nucleic acid oligomer characterized by comprising bringing a specific nucleic acid oligomer into contact with fluoride ions in the presence of a radical reaction inhibitor.

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Inventors:
MIYAGAWA TAKUYA (JP)
Application Number:
PCT/JP2023/010891
Publication Date:
September 28, 2023
Filing Date:
March 20, 2023
Export Citation:
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Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07H21/02; C12N15/113
Domestic Patent References:
WO2022009959A12022-01-13
WO2021210409A12021-10-21
WO2013027843A12013-02-28
Other References:
UMEMOTO, T. ; WADA, T.: "Oligoribonucleotide synthesis by the use of 1-(2-cyanoethoxy)ethyl (CEE) as a 2'-hydroxy protecting group", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 45, no. 52, 20 December 2004 (2004-12-20), Amsterdam , NL , pages 9529 - 9531, XP027297909, ISSN: 0040-4039
UMEMOTO TADASHI, WADA TAKESHI: "Oligoribonucleotide synthesis by the use of 1-(2cyanoethoxy)ethyl (CEE) as a 2'-hydroxy protecting group", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 48, no. 1, 1 November 2004 (2004-11-01), pages 9 - 10, XP093095607, DOI: 10.1093/nass/48.1.9
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (JP)
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