Title:
METHOD FOR SYNTHESIZING CIS-2-METHYL-7-OCTADECENE AND CIS-7,8-EPOXY-2-METHYLOCTADECANE
Document Type and Number:
WIPO Patent Application WO/2024/040754
Kind Code:
A1
Abstract:
The present invention relates to the technical field of organic synthesis, and provides a method for synthesizing cis-2-methyl-7-octadecene and cis-7,8-epoxy-2-methyloctadecane. According to the present invention, N-sulfonylhydrazone and phosphine salt are taken as raw materials, cis-2-methyl-7-octadecene can be obtained by a one-step method under the action of an organic base, and the generation of trans-2-methyl-7-octadecene can be avoided. The yield and the purity of the cis-2-methyl-7-octadecene obtained in the present invention are both high, the yield of the cis-2-methyl-7-octadecene is 68-96%, and the purity of the cis-2-methyl-7-octadecene is higher than 98.8%. Because the cis-2-methyl-7-octadecene has high purity, the yield and the purity of the cis-7,8-epoxy-2-methyloctadecane obtained in the present invention are both high, the yield of the cis-7,8-epoxy-2-methyloctadecane is higher than 90%, and the purity of the cis-7,8-epoxy-2-methyloctadecane is higher than 99%.
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Inventors:
HAO DEJUN (CN)
GAO SHUXIAN (CN)
GAO SHUXIAN (CN)
Application Number:
PCT/CN2022/131263
Publication Date:
February 29, 2024
Filing Date:
November 11, 2022
Export Citation:
Assignee:
NANJING FANMAO BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C1/34; C07C11/02; C07D301/14; C07D303/04
Foreign References:
| US20130231499A1 | 2013-09-05 | |||
| US5463149A | 1995-10-31 |
Other References:
I. UJVARY, E. VOIGT, K. LESKO: "ChemInform Abstract: Synthesis of a Possible Degradation Product of (.+-.)-Disparlure, the Sex Pheromone of the Gypsy Moth, Lymantria dispar.", CHEMINFORM, ELECTROCHEMICAL SOCIETY, vol. 19, no. 41, 11 October 1988 (1988-10-11), pages 152, XP009553001, ISSN: 0931-7597, DOI: 10.1002/chin.198841318
NARAYANA C., REDDY N. K., KABALKA G. W.: "Sodium Percarbonate: A Mild Reagent for Conversion of Tosylhydrazones and Nitroalkanes to Carbonyl Compounds", SYNTHETIC COMMUNICATIONS, vol. 22, no. 17, 31 December 1992 (1992-12-31), US , pages 2587 - 2592, XP009553229, ISSN: 0039-7911, DOI: 10.1080/00397919208021655
NARAYANA C., REDDY N. K., KABALKA G. W.: "Sodium Percarbonate: A Mild Reagent for Conversion of Tosylhydrazones and Nitroalkanes to Carbonyl Compounds", SYNTHETIC COMMUNICATIONS, vol. 22, no. 17, 31 December 1992 (1992-12-31), US , pages 2587 - 2592, XP009553229, ISSN: 0039-7911, DOI: 10.1080/00397919208021655
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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