Title:
MODIFIED IMMUNE CELL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011434
Kind Code:
A1
Abstract:
Provided is a method for culturing immune cells, which method comprises reducing the expression of and/or attenuating the activity of a YEATS domain protein family member of immune cells and/or a functional active fragment thereof. Also provided is an immune cell obtained by means of the method, and the use thereof in the preparation of a drug for preventing and/or treating tumors.
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Inventors:
LIU YARONG (CN)
SUN JINGWEI (CN)
SHENG YAO (CN)
SUN JINGWEI (CN)
SHENG YAO (CN)
Application Number:
PCT/CN2022/109580
Publication Date:
February 09, 2023
Filing Date:
August 02, 2022
Export Citation:
Assignee:
SUZHOU GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/078; A61P35/00; C12N5/0781; C12N5/0783; C12N5/0784; C12N5/0786; C12N5/0787
Domestic Patent References:
| WO2021127166A1 | 2021-06-24 |
Foreign References:
| CN111615517A | 2020-09-01 |
Other References:
CAI WENCHEN, SHIHUI ZHANG, YIBING GAO, WANLI NIU, HONG XU, FANG YANG: "N-acetyl-seranyl-aspartate-lysyl-proline Attenuates Silicosis by Inhibiting YEATS4", CHINESE JOURNAL OF COMPARATIVE MEDICINE, CHINESE SOCIETY OF LABORATORY ANIMALS; CHINESE ACADEMY OF MEDICAL SCIENCES, CN, vol. 31, no. 5, 29 April 2021 (2021-04-29), CN , pages 22 - 27, XP093032334, ISSN: 1671-7856, DOI: 10.3969/j.issn.1671-7856.2021.05.004
GARNAR-WORTZEL, L. ET AL.: "Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia", ACS CENTRAL SCIENCE, vol. 7, no. 5, 30 April 2021 (2021-04-30), XP055935704, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c01550
ZHOU, JIANBIAO ET AL.: "ENL: Structure, Function, and Roles in Hematopoiesis and Acute Myeloid Leukemia", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 75, no. 21, 31 July 2018 (2018-07-31), XP036602075, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2895-8
GARNAR-WORTZEL, L. ET AL.: "Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia", ACS CENTRAL SCIENCE, vol. 7, no. 5, 30 April 2021 (2021-04-30), XP055935704, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c01550
ZHOU, JIANBIAO ET AL.: "ENL: Structure, Function, and Roles in Hematopoiesis and Acute Myeloid Leukemia", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 75, no. 21, 31 July 2018 (2018-07-31), XP036602075, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2895-8
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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