Title:
MUCOSAL VACCINE COMPOSITION FOR BOVINE MASTITIS
Document Type and Number:
WIPO Patent Application WO/2020/027318
Kind Code:
A1
Abstract:
A mucosal vaccine composition for preventing bovine mastitis, which comprises: an antigen originated from Staphylococcus aureus; and a nano gel comprising a polysaccharide having a cationic functional group and a hydrophobic functional group in side chains thereof. When the composition is administered to a cow, the titer of an antibody against Staphylococcus aureus increases immediately after the contact with the bacterium in the breast of the cow. Therefore, the composition can prevent the occurrence of mastitis in the cow.
Inventors:
HAYASHI TOMOHITO (JP)
KIKU YOSHIO (JP)
NAGASAWA YUYA (JP)
AKIYOSHI KAZUNARI (JP)
SAWADA SHIN-ICHI (JP)
ASO HISASHI (JP)
NOCHI TOMONORI (JP)
KIKU YOSHIO (JP)
NAGASAWA YUYA (JP)
AKIYOSHI KAZUNARI (JP)
SAWADA SHIN-ICHI (JP)
ASO HISASHI (JP)
NOCHI TOMONORI (JP)
Application Number:
PCT/JP2019/030451
Publication Date:
February 06, 2020
Filing Date:
August 02, 2019
Export Citation:
Assignee:
NAT AGRICULTURE & FOOD RES ORG (JP)
UNIV KYOTO (JP)
UNIV TOHOKU (JP)
UNIV KYOTO (JP)
UNIV TOHOKU (JP)
International Classes:
A61K39/085; A61K9/06; A61K47/36; A61P15/14
Domestic Patent References:
| WO2000012564A1 | 2000-03-09 | |||
| WO2014054588A1 | 2014-04-10 |
Foreign References:
| JP2010105968A | 2010-05-13 | |||
| JP2009286730A | 2009-12-10 | |||
| JP2015151375A | 2015-08-24 |
Other References:
OKAMOTO, TAKAYUKI: "Review on mucosal immunity induction therapy for mastitis caused by staphylococcus aureus", JOURNAL OF THE JAPAN VETERINARY MEDICAL ASSOCIATION, vol. 67, no. 9, 2014, pages 700 - 701, XP009526160, ISSN: 0446-6454
HAYASHI, TOMOHITO: "Special feature Mastitis 2013 - Second part: Introduction of latest research -, Trial of development of mucosal immune mechanism and mastitis vaccine using it", JOURNAL OF CLINICAL VETERINARY MEDICINE, vol. 31, no. 6, 1 June 2013 (2013-06-01), pages 32 - 36, XP009526167, ISSN: 0912-1501
TOMOHITO HAYASHI: "How far has the development of vaccines for mastitis progressed? / Limelight to the mucosal immunity system that is completely different from systemic immunity", DAIRMAN, vol. 63, no. 9, 2013, pages 40 - 41, XP009526100, ISSN: 0416-6272
HAYASHI, TOMOHITO: "Development of the mucosal vaccine for bovine mastitis based on the mucosal immune system", JAPANESE JOURNAL OF LARGE ANIMAL CLINICS, vol. 7, no. 3, 1 November 2016 (2016-11-01), pages 131 - 139, XP009526099
KIKU, Y. ET AL.: "The cell wall component lipoteichoic acid of Staphylococcus aureus induces chemokine gene expression in bovine mammary epithelial cells.", J VET MED SCI., vol. 78, no. 9, 2016, pages 1505 - 1510, XP055782332
BOERHOUT E. ET AL., VET RES., vol. 46, 28 September 2015 (2015-09-28), pages 115
ASHRAF S. ET AL., SCI REP., vol. 7, 19 January 2017 (2017-01-19), pages 40608
ALMEIDA RA. ET AL., J DAIRY SCI., vol. 79, no. 6, 1996, pages 1021 - 1026
AYAME H. ET AL., BIOCONJUG. CHEM., vol. 19, 2008, pages 882 - 890
KIKU Y. ET AL., J VET MED SCI, vol. 78, 2016, pages 1505 - 1510
HATA E. ET AL., J VET MED SCI, vol. 72, 2010, pages 647 - 652
AKIYOSHI K. ET AL., J. CONTROL. RELEASE, vol. 54, 1998, pages 313 - 320
NAGASAWA Y. ET AL., ANIM SCI J., vol. 89, 2018
See also references of EP 3831405A4
HAYASHI, TOMOHITO: "Special feature Mastitis 2013 - Second part: Introduction of latest research -, Trial of development of mucosal immune mechanism and mastitis vaccine using it", JOURNAL OF CLINICAL VETERINARY MEDICINE, vol. 31, no. 6, 1 June 2013 (2013-06-01), pages 32 - 36, XP009526167, ISSN: 0912-1501
TOMOHITO HAYASHI: "How far has the development of vaccines for mastitis progressed? / Limelight to the mucosal immunity system that is completely different from systemic immunity", DAIRMAN, vol. 63, no. 9, 2013, pages 40 - 41, XP009526100, ISSN: 0416-6272
HAYASHI, TOMOHITO: "Development of the mucosal vaccine for bovine mastitis based on the mucosal immune system", JAPANESE JOURNAL OF LARGE ANIMAL CLINICS, vol. 7, no. 3, 1 November 2016 (2016-11-01), pages 131 - 139, XP009526099
KIKU, Y. ET AL.: "The cell wall component lipoteichoic acid of Staphylococcus aureus induces chemokine gene expression in bovine mammary epithelial cells.", J VET MED SCI., vol. 78, no. 9, 2016, pages 1505 - 1510, XP055782332
BOERHOUT E. ET AL., VET RES., vol. 46, 28 September 2015 (2015-09-28), pages 115
ASHRAF S. ET AL., SCI REP., vol. 7, 19 January 2017 (2017-01-19), pages 40608
ALMEIDA RA. ET AL., J DAIRY SCI., vol. 79, no. 6, 1996, pages 1021 - 1026
AYAME H. ET AL., BIOCONJUG. CHEM., vol. 19, 2008, pages 882 - 890
KIKU Y. ET AL., J VET MED SCI, vol. 78, 2016, pages 1505 - 1510
HATA E. ET AL., J VET MED SCI, vol. 72, 2010, pages 647 - 652
AKIYOSHI K. ET AL., J. CONTROL. RELEASE, vol. 54, 1998, pages 313 - 320
NAGASAWA Y. ET AL., ANIM SCI J., vol. 89, 2018
See also references of EP 3831405A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Download PDF: