MUTATED ISOPROPYLMALATE ISOMERASE - KYOWA HAKKO KOGYO KK

Title:

MUTATED ISOPROPYLMALATE ISOMERASE

Document Type and Number:

WIPO Patent Application WO/2003/078620

Kind Code:

A1

Abstract:

It is intended to provide a polypeptide having an amino acid sequence which is derived from the amino acid sequence of isopropylmalate isomerase originating in a microorganism belonging to coryneform bacteria by deletion, substitution or addition of one or more amino acids characterized in that a coryneform bacterium producing the polypeptide having the above amino acid sequence as a sole isopropylmalate isomerase exhibits a partial leucine requirement in the minimum medium; a DNA encoding the polypeptide; a recombinant DNA having the DNA; a microorganism transformed by the recombinant DNA; and a process for producing an L-amino acid with the use of the microorganism.

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Inventors:

IKEDA MASATO (JP)
HAYASHI MIKIRO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
MIZOGUCHI HIROSHI (JP)
NAKAGAWA SATOSHI (JP)

Application Number:

PCT/JP2003/003353

Publication Date:

September 25, 2003

Filing Date:

March 19, 2003

Export Citation:

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Assignee:

KYOWA HAKKO KOGYO KK (JP)
IKEDA MASATO (JP)
HAYASHI MIKIRO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
MIZOGUCHI HIROSHI (JP)
NAKAGAWA SATOSHI (JP)

International Classes:

C12N1/21; C12N9/88; C12N15/61; C12P13/04; C12P13/08; C12P13/10; C12P13/14; C12P13/22; C12P13/24; (IPC1-7): C12N9/90; C12N15/61; C12N1/21; C12P13/08; C12P13/14; C12P13/10; C12P13/22; C12N9/90; C12P13/24

Domestic Patent References:

WO2003054179A1

2003-07-03

Foreign References:

EP1108790A2	2001-06-20
EP1108790A2	2001-06-20

Other References:

SAHM HERMANN ET AL.: "Isolation and prominent characteristics of an L-lysine hyperproducing strain of corynebacterium glutamicum", APPL. MICROBIOL. BIOTECHNOL., vol. 37, 1992, pages 566 - 571, XP000979296
SAHM HERMANN ET AL.: "Leucine synthesis in corynebacterium glutamicum: Enzyme activities, structure of leuA and effect of leuA inactivation on lysine synthesis", APPL. MICROBIOL. BIOTECHNOL., vol. 60, no. 1, 1994, pages 133 - 140, XP008014707

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