Title:
NANOGEL-COATED VACCINE
Document Type and Number:
WIPO Patent Application WO/2022/210465
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composite of a nanogel with an antigen not contained in nanogel, and a vaccine formulation that contains this composite. Specifically, the present invention provides a nanogel/vaccine antigen composite, wherein the vaccine antigen is coated by nanogel.
Inventors:
KIYONO HIROSHI (JP)
YUKI YOSHIKAZU (JP)
YUKI YOSHIKAZU (JP)
Application Number:
PCT/JP2022/014798
Publication Date:
October 06, 2022
Filing Date:
March 28, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
HANAVAX INC (JP)
HANAVAX INC (JP)
International Classes:
A61K39/00; A61K39/12; A61K39/39; A61K47/36; A61P31/12; A61P31/14; A61P37/04
Domestic Patent References:
| WO2020027318A1 | 2020-02-06 | |||
| WO2010050578A1 | 2010-05-06 | |||
| WO2000012564A1 | 2000-03-09 |
Foreign References:
| JP2010105968A | 2010-05-13 |
Other References:
TANIMOTO, TAKESHI: "Development of nasal absorption influenza vaccine", DRUG DELIVERY SYSTEM., NIHON D D S GAKKAI, JAPAN, vol. 25, no. 1, 1 January 2010 (2010-01-01), Japan , pages 15 - 21, XP009540039, ISSN: 0913-5006
LISSETTE S. VELASQUEZ; SAMANTHA SHIRA; ALICE N. BERTA; JACQUELYN KILBOURNE; BABU M. MEDI; IAN TIZARD; YAWEI NI; CHARLES J. ARNTZEN: "Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 32, 11 May 2011 (2011-05-11), AMSTERDAM, NL , pages 5221 - 5231, XP028239816, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2011.05.027
AYAME ET AL., BIOCONJUG CHEM, vol. 19, 2008, pages 882 - 890
NOCHI ET AL., NAT MATER, vol. 9, 2010, pages 572 - 578
YUKI ET AL., BIOTECHNOL GENET ENG REV, vol. 29, 2013, pages 61 - 72
KONG ET AL., INFECT IMMUN, vol. 81, 2013, pages 1625 - 1634
YUKI ET AL., MOL. PHARMACEUTICS, vol. 18, 2021, pages 1582 - 1592
YUKI ET AL., MOLECULAR PHARMACEUTICS, 2021, Retrieved from the Internet
AYAME ET AL., BIOCONJUGATE CHEM, vol. 19, 2008, pages 882 - 890
KURODA ET AL., LANGMUIR, vol. 18, 2002, pages 3780 - 3786
GLASS ET AL., N. ENGL. J. MED, vol. 361, 2009, pages 1776 - 1785
SATO ET AL., CELL MOL GASTROENTEROL HEPATOL, vol. 7, 2019, pages 686 - 688
YUKI ET AL., MOLECULAR PHARMACEUTICS, Retrieved from the Internet
ATMA ET AL., N. ENG. J. MED., vol. 365, 2011, pages 2187 - 87
MUTSCH ET AL., N. ENLG. J MED, vol. 350, 2004, pages 896 - 903
YUKI ET AL., J. IMMUNOL., vol. 185, 2010, pages 5436 - 5443
FUKUYAMA ET AL., MUCOSAL IMMUNOL., vol. 8, 2015, pages 1144 - 1153
YUKI ET AL., J . IMMUNOL, vol. 185, 2010, pages 5436 - 5443
LISSETTE S. VELASQUEZ; SAMANTHA SHIRA; ALICE N. BERTA; JACQUELYN KILBOURNE; BABU M. MEDI; IAN TIZARD; YAWEI NI; CHARLES J. ARNTZEN: "Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 32, 11 May 2011 (2011-05-11), AMSTERDAM, NL , pages 5221 - 5231, XP028239816, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2011.05.027
AYAME ET AL., BIOCONJUG CHEM, vol. 19, 2008, pages 882 - 890
NOCHI ET AL., NAT MATER, vol. 9, 2010, pages 572 - 578
YUKI ET AL., BIOTECHNOL GENET ENG REV, vol. 29, 2013, pages 61 - 72
KONG ET AL., INFECT IMMUN, vol. 81, 2013, pages 1625 - 1634
YUKI ET AL., MOL. PHARMACEUTICS, vol. 18, 2021, pages 1582 - 1592
YUKI ET AL., MOLECULAR PHARMACEUTICS, 2021, Retrieved from the Internet
AYAME ET AL., BIOCONJUGATE CHEM, vol. 19, 2008, pages 882 - 890
KURODA ET AL., LANGMUIR, vol. 18, 2002, pages 3780 - 3786
GLASS ET AL., N. ENGL. J. MED, vol. 361, 2009, pages 1776 - 1785
SATO ET AL., CELL MOL GASTROENTEROL HEPATOL, vol. 7, 2019, pages 686 - 688
YUKI ET AL., MOLECULAR PHARMACEUTICS, Retrieved from the Internet
ATMA ET AL., N. ENG. J. MED., vol. 365, 2011, pages 2187 - 87
MUTSCH ET AL., N. ENLG. J MED, vol. 350, 2004, pages 896 - 903
YUKI ET AL., J. IMMUNOL., vol. 185, 2010, pages 5436 - 5443
FUKUYAMA ET AL., MUCOSAL IMMUNOL., vol. 8, 2015, pages 1144 - 1153
YUKI ET AL., J . IMMUNOL, vol. 185, 2010, pages 5436 - 5443
Attorney, Agent or Firm:
OKUHARA Koji (JP)
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