Title:
NEUTRAL AND ANIONIC COLLOIDAL PARTICLES FOR GENE DELIVERY
Document Type and Number:
WIPO Patent Application WO2002043769
Kind Code:
A3
Abstract:
Processes for making neutral or anionic complexes containing sequestered DNA for gene transfer, by forming a stable colloid containing an aqueous phase having suspended therein a first DNA complex with a cationic surface potential comprising a DNA sequence complexed with a cationic lipid or polymer, and modifying the surface potential of the first DNA complex to form a stable colloid comprising a second DNA complex with a neutral or net anionic surface potential.
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Inventors:
HOFLAND HANS (US)
LAMONS DONALD (US)
MENG XIAO-YING (US)
LAMONS DONALD (US)
MENG XIAO-YING (US)
Application Number:
PCT/EP2001/013800
Publication Date:
October 09, 2003
Filing Date:
November 27, 2001
Export Citation:
Assignee:
GENCELL SA (FR)
HOFLAND HANS (US)
LAMONS DONALD (US)
MENG XIAO-YING (US)
HOFLAND HANS (US)
LAMONS DONALD (US)
MENG XIAO-YING (US)
International Classes:
A61K31/7088; A61K47/26; A61K47/34; A61K47/42; A61K47/48; A61K48/00; A61P43/00; (IPC1-7): A61K47/48
Domestic Patent References:
| WO1998008489A1 | 1998-03-05 | |||
| WO1998054130A1 | 1998-12-03 |
Other References:
FINSINGER D ET AL: "PROTECTIVE COPOLYMERS FOR NONVIRAL GENE VECTORS: SYNTHESIS, VECTOR CHARACTERIZATION AND APPLICATION IN GENE DELIVERY", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 7, no. 14, July 2000 (2000-07-01), pages 1183 - 1192, XP001005915, ISSN: 0969-7128
VERRECCHIA T ET AL: "Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 36, no. 1, 1 September 1995 (1995-09-01), pages 49 - 61, XP000525974, ISSN: 0168-3659
FREDERIC M ET AL: "Introduction of cyclic guanidines into cationic lipids for non-viral gene delivery", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 5, January 2000 (2000-01-01), pages 675 - 679, XP004187753, ISSN: 0040-4039
PITARD B ET AL: "Sterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivo.", THE JOURNAL OF GENE MEDICINE. ENGLAND 2001 SEP-OCT, vol. 3, no. 5, September 2001 (2001-09-01), pages 478 - 487, XP008013418, ISSN: 1099-498X
VERRECCHIA T ET AL: "Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 36, no. 1, 1 September 1995 (1995-09-01), pages 49 - 61, XP000525974, ISSN: 0168-3659
FREDERIC M ET AL: "Introduction of cyclic guanidines into cationic lipids for non-viral gene delivery", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 5, January 2000 (2000-01-01), pages 675 - 679, XP004187753, ISSN: 0040-4039
PITARD B ET AL: "Sterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivo.", THE JOURNAL OF GENE MEDICINE. ENGLAND 2001 SEP-OCT, vol. 3, no. 5, September 2001 (2001-09-01), pages 478 - 487, XP008013418, ISSN: 1099-498X
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