Title:
N,N-DISUBSTITUTED AMIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1996/005169
Kind Code:
A1
Abstract:
A compound represented by general formula (I), a medicinally acceptable salt or ester thereof, and an antineoplastic containing the same as the active ingredient, wherein Ar1, Ar2, Ar3 and Ar4 represent each aryl or heteroaryl, A represents an optionally substituted hydrocarbon group; X and Y represent each oxygen, sulfur, carbonyl, -CHRa- (Ra being hydrogen or lower alkyl) or -NRb- (Rb being hydrogen or lower alkyl), or X and Y are combined together to represent vinylene or ethynylene; R1, R2, R3, R8 and R9 represent each hydrogen, halogeno, hydroxy, lower alkyl or lower alkoxy; R4 and R5 represent each hydrogen, halogeno, hydroxy, amino, nitro, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl or lower alkoxy; R6 represents lower alkyl; and R7 represents hydrogen or lower alkyl; provided when one of X and Y represents oxygen, sulfur or -NRb-, the other of them represents carbonyl or -CHRa-.
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Inventors:
IWASAWA YOSHIKAZU (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)
Application Number:
PCT/JP1995/001589
Publication Date:
February 22, 1996
Filing Date:
August 10, 1995
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
IWASAWA YOSHIKAZU (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)
IWASAWA YOSHIKAZU (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)
International Classes:
A01N37/00; A61K31/19; A61K31/215; A61K31/505; C07C233/13; C07C233/25; C07C233/47; C07D213/81; C07D239/42; C07D261/18; C07D271/06; C07D307/42; C07D307/68; C07D405/12; C07D407/06; C07D409/14; C07D417/12; (IPC1-7): C07C233/13; A61K31/19; A61K31/34; A61K31/36; A61K31/38; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/47; C07C233/25; C07D213/56; C07D215/12; C07D235/14; C07D263/56; C07D277/64; C07D307/52; C07D307/81; C07D317/60; C07D333/20; C07D413/12; C07D413/14
Foreign References:
| JPH05213992A | 1993-08-24 | |||
| JPH05279290A | 1993-10-26 |
Other References:
See also references of EP 0805154A4
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