NOVEL ALKYL DIPHENYLMETHANE PROTECTION AGENT

Title:

NOVEL ALKYL DIPHENYLMETHANE PROTECTION AGENT

Document Type and Number:

WIPO Patent Application WO/2019/123994

Kind Code:

A1

Abstract:

Provided is an alkyl diphenylmethane protection agent that does not solidify or insolubilize a compound, a functional group of which is protected thereby, while making separation and purification after reaction easy. An alkyl diphenylmethane compound which is represented by general formula (1). (In the formula, Y represents -OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), -NHR20 (wherein R20 represents a hydrogen atom, a linear or branched alkyl group having 1-6 carbon atoms or an aralkyl group), an isocyanate group, an azide group or a halogen atom; Z represents a linear or branched alkyl group having 1-4 carbon atoms, an alkenyl group or a cycloalkyl group; at least one of R1-R10 represents a group that is represented by formula (2), and the rest represent a hydrogen atom, a halogen atom, an alkyl group having 1-4 carbon atoms or an alkoxy group having 1-4 carbon atoms; R11 represents a linear or branched alkylene group having 1-16 carbon atoms; X represents O or CONR21 (wherein R21 represents a hydrogen atom or an alkyl group having 1-4 carbon atoms); and A represents a group represented by formula (3) or the like (wherein R12, R13 and R14 may be the same or different, and each represents a linear or branched alkyl group having 1-6 carbon atoms or optionally substituted aryl group; R15 represents a single bond or a linear or branched alkylene group having 1-3 carbon atoms; and each of R16, R17 and R18 represents a linear or branched alkylene group having 1-3 carbon atoms).)

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Inventors:

YANO SHINYA (JP)
SAITO KENTA (JP)
KUBOTA HIDEKI (JP)

Application Number:

PCT/JP2018/043565

Publication Date:

June 27, 2019

Filing Date:

November 27, 2018

Export Citation:

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Assignee:

SEKISUI MEDICAL CO LTD (JP)

International Classes:

C07F7/18; C07B51/00; C07K1/06

Domestic Patent References:

WO2010113939A1	2010-10-07
WO2016140232A1	2016-09-09
WO2017038650A1	2017-03-09
WO2017221889A1	2017-12-28
WO2018021233A1	2018-02-01
WO2018088527A1	2018-05-17
WO2018155669A1	2018-08-30
WO2012029794A1	2012-03-08
WO2010113939A1	2010-10-07
WO2017038650A1	2017-03-09

Foreign References:

EP1510522A1	2005-03-02
JP2000500740A	2000-01-25

Other References: