Title:
NOVEL INDENONE DERIVATIVES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/005578
Kind Code:
A1
Abstract:
The present invention relates to novel indenone derivatives, isomers thereof or pharmaceutically acceptable salts thereof, and uses thereof. The indenone derivatives according to the present invention may be advantageously used for (i) the suppression of amyloid-beta aggregation and/or the decomposition of the aggregates, (ii) the suppression of tau protein aggregation and/or the decomposition of the aggregates, and/or (iii) the prevention or treatment of neurodegenerative brain disease by inhibiting the hyperphosphorylation of tau protein.
Inventors:
KIM SEONG MUK (KR)
KIM HYE JU (KR)
KIM HYE JU (KR)
Application Number:
PCT/KR2023/009159
Publication Date:
January 04, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
AMYLOID SOLUTION INC (KR)
International Classes:
C07D417/10; A23L33/10; A61K31/426; A61K31/4436; A61K31/4439; A61K31/5377; A61P25/28; C07D277/22; C07D401/10; C07D409/10
Domestic Patent References:
| WO2008107321A1 | 2008-09-12 | |||
| WO1993008799A1 | 1993-05-13 |
Foreign References:
| KR20050100051A | 2005-10-18 |
Other References:
HUANG LING; MIAO HUI; SUN YANG; MENG FANCHAO; LI XINGSHU: "Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 87, 26 September 2014 (2014-09-26), AMSTERDAM, NL , pages 429 - 439, XP029019091, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.09.081
NEL MAGDALENA S.; PETZER ANéL; PETZER JACOBUS P.; LEGOABE LESETJA J.: "2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 19, 22 August 2016 (2016-08-22), Amsterdam NL , pages 4599 - 4605, XP029718543, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.08.067
NEL MAGDALENA S.; PETZER ANéL; PETZER JACOBUS P.; LEGOABE LESETJA J.: "2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 26, no. 19, 22 August 2016 (2016-08-22), Amsterdam NL , pages 4599 - 4605, XP029718543, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.08.067
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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