Title:
NOVEL METHOD FOR SYNTHESISING (2S, 3AS, 7AS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND THE ESTERS THEREOF AND THE USE THEREOF FOR PERINDOPRIL SYNTHESIS
Document Type and Number:
WIPO Patent Application WO2004078707
Kind Code:
A3
Abstract:
The invention relates to a method for synthesising derivatives of the formula (I), wherein R is a hydrogen atom or an amine function-protecting group. The use of said derivatives for synthesising perindopril and the pharmaceutically acceptable salts thereof is also disclosed.
Inventors:
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
LANGLOIS PASCAL (FR)
Application Number:
PCT/FR2004/000444
Publication Date:
October 14, 2004
Filing Date:
February 27, 2004
Export Citation:
Assignee:
SERVIER LAB (FR)
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
International Classes:
C07D209/42; (IPC1-7): C07D209/42
Domestic Patent References:
| WO2003016336A1 | 2003-02-27 | |||
| WO2001058868A1 | 2001-08-16 |
Foreign References:
| US4933361A | 1990-06-12 | |||
| EP0937714A1 | 1999-08-25 |
Other References:
VINCENT M ET AL: "Stereoselective Synthesis of a New Perhydroindole Derivative of Chiral Iminodiacid, a Potent Inhibitor of Agiotensin Converting Enzyme", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 23, no. 16, 1982, pages 1677 - 1680, XP002155080, ISSN: 0040-4020
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