NOVEL THIAZINE OR PYRAZINE DERIVATIVES - SANTEN PHARMACEUTICAL CO LTD

Title:

NOVEL THIAZINE OR PYRAZINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2001/007419

Kind Code:

A1

Abstract:

Novel compounds having as the main skeleton 3-oxo-3,4-dihydro-2H-1,4-thiazine or 2-oxo-1,2,3,4-tetrahydropyrazine, which are represented by general formula [I]: wherein X is S or R?6¿-(A¿2?)-N; R?1¿ to R?4¿ are each H, alkyl, cycloalkyl, (hetero)aryl, or the like; R?5¿ is H, alkyl, cycloalkyl, aryl, or -A¿3?-A¿4?-R?7¿; R?6¿ is H, (cyclo)alkyl, OH, alkoxy, aryl, aryloxy, or the like; R?7¿ is H, alkyl, OH, alkoxy, aryl, aryloxy, (substituted) amino, or a heterocyclic group; A¿1? and A¿3? are each alkylene; A¿2? is carbonyl or sulfonyl; and A¿4? is carbonyl or oxalyl.

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Inventors:

MATSUMOTO JUNZO DI
NISHIMURA KAZUO (JP)
BAN MASAKAZU (JP)
FUJIMURA KEN-ICHI (JP)
KOBAYASHI NAOYUKI (JP)
HORI MASANORI (JP)
HONDA TAKAHIRO (JP)

Application Number:

PCT/JP2000/004964

Publication Date:

February 01, 2001

Filing Date:

July 26, 2000

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
MATSUMOTO EIKO HF (JP)
NISHIMURA KAZUO (JP)
BAN MASAKAZU (JP)
FUJIMURA KEN ICHI (JP)
KOBAYASHI NAOYUKI (JP)
HORI MASANORI (JP)
HONDA TAKAHIRO (JP)

International Classes:

A61P9/04; A61P43/00; C07D241/08; C07D401/12; C07D401/14; C07D403/12; C07D409/12; C07D413/12; C07D417/12; C07K5/02; C07K5/06; C07K5/078; C07K5/097; A61K38/00; (IPC1-7): C07D241/08; C07D279/12; C07D403/12; C07D417/12; A61L31/495; A61K31/54; A61P43/00

Foreign References:

EP0666261A1	1995-08-09
EP0643072A1	1995-03-15
JPH02275869A	1990-11-09
JPS5835176A	1983-03-01

Other References: