PROCESS FOR PRODUCING alpha-HYDROXYIMINOPHENYLACETONITRILE

WIPO Patent Application WO/1995/001329

A1

A process for producing an alpha-hydroxyiminophenylacetonitrile represented by general formula [II], (wherein R1, R2, R3 and Z are each as defined in the specification) by reacting a crude nitrile containing a phenylacetonitrile represented by general formula [I], (wherein R1, R2, R3 and Z are each as defined in the specification) with an alkyl nitrite in the presence of a base, extracting the reaction mixture with water, and neutralizing the separated water layer with an acid. This process enables target alpha-hydroxyiminophenylacetonitriles to be readily produced in a highly pure form in high yield by extracting the reaction mass with water and neutralizing the separated water layer with an acid.

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TAKASE AKIRA (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)

PCT/JP1994/001076

January 12, 1995

July 01, 1994

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SHIONOGI & CO (JP)
SUMITOMO CHEMICAL CO (JP)
TAKASE AKIRA (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)

C07C251/48; C07C253/14; C07C253/30; C07C255/64; (IPC1-7): C07C255/62; C07C253/30; C07C323/63; C07C319/20

JPH0489464A	1992-03-23
JPS54163548A	1979-12-26
JPH06219986A	1994-08-09

See also references of EP 0658542A4

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