Title:
PHARMACEUTICAL COMPOSITION FOR RADIOTHERAPY, AND METHOD FOR TREATING SOLID CANCER USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/176872
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition to be used for radiotherapy that comprises a compound represented by formula (I) [wherein: R1 is an aryl group substituted by a substituent selected from an iodine atom, etc., wherein the aryl group may be optionally substituted by a substituent such as a hydroxy group; X is a bond, etc.; and ring A is a group represented by formula (A), wherein R2 is a non-aromatic heterocyclic group which may be optionally substituted by one or more C1-C4 alkyl groups] or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also provided are nanoparticles and a method for treating solid cancer, each using the aforesaid compound.
Inventors:
TAMANOI FUYUHIKO (JP)
MATSUMOTO KOTARO (JP)
HIGASHI YUYA (JP)
MATSUMOTO KOTARO (JP)
HIGASHI YUYA (JP)
Application Number:
PCT/JP2023/010023
Publication Date:
September 21, 2023
Filing Date:
March 15, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K41/00; A61K9/18; A61K31/496; A61K47/04; A61P35/00
Domestic Patent References:
| WO2021060498A1 | 2021-04-01 |
Foreign References:
| JPH04507399A | 1992-12-24 |
Other References:
YASUI LINDA S., CHEN KAI, WANG KETAI, JONES T. PATRICK, CALDWELL JAMES, GUSE DIANA, KASSIS AMIN I.: "Using Hoechst 33342 to Target Radioactivity to the Cell Nucleus", RADIATION RESEARCH, ACADEMIC PRESS INC., US, vol. 167, no. 2, 1 February 2007 (2007-02-01), US , pages 167 - 175, XP009548985, ISSN: 0033-7587, DOI: 10.1667/RR0584.1
ONOUE, RYOTARO ET AL.: "Development of radio iodinated BODIPY-conjugated Hoechst for Auger Therapy", PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 142, 26H-pm01S, 4 March 2022 (2022-03-04)
ONOUE RYOTARO, WATANABE HIROYUKI, ONO MASAHIRO: "Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 59, no. 7, 19 January 2023 (2023-01-19), UK , pages 928 - 931, XP093091332, ISSN: 1359-7345, DOI: 10.1039/D2CC05405A
"DNA Damage and Double Strand Breaks - Part A Series: -the Enzymes", vol. 51, 1 September 2022, ELSEVIER, ISBN: 9780323993975, ISSN: 1874-6047, article HIGASHI YUYA, MA YUE, MATSUMOTO KOTARO, SHIRO AYUMI, SAITOH HIROYUKI, KAWACHI TETSUYA, TAMANOI FUYUHIKO: "Chapter 7: Auger electrons and DNA double-strand breaks studied by using iodine-containing chemicals", pages: 101 - 115, XP009548995, DOI: 10.1016/bs.enz.2022.08.007
ONOUE, RYOTARO ET AL.: "Development of radio iodinated BODIPY-conjugated Hoechst for Auger Therapy", PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 142, 26H-pm01S, 4 March 2022 (2022-03-04)
ONOUE RYOTARO, WATANABE HIROYUKI, ONO MASAHIRO: "Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 59, no. 7, 19 January 2023 (2023-01-19), UK , pages 928 - 931, XP093091332, ISSN: 1359-7345, DOI: 10.1039/D2CC05405A
"DNA Damage and Double Strand Breaks - Part A Series: -the Enzymes", vol. 51, 1 September 2022, ELSEVIER, ISBN: 9780323993975, ISSN: 1874-6047, article HIGASHI YUYA, MA YUE, MATSUMOTO KOTARO, SHIRO AYUMI, SAITOH HIROYUKI, KAWACHI TETSUYA, TAMANOI FUYUHIKO: "Chapter 7: Auger electrons and DNA double-strand breaks studied by using iodine-containing chemicals", pages: 101 - 115, XP009548995, DOI: 10.1016/bs.enz.2022.08.007
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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