Title:
PHARMACEUTICAL COMPOSITION WHICH IMPROVES IN VIVO GENE TRANSFER
Document Type and Number:
WIPO Patent Application WO2003066104
Kind Code:
A3
Abstract:
The invention relates to a pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine) and preferably taking the form of one of the cationic mineral or organic salts thereof. The inventive composition can be used to improve in vivo gene transfer.
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Inventors:
PITARD BRUNO (FR)
Application Number:
PCT/FR2003/000407
Publication Date:
March 25, 2004
Filing Date:
February 07, 2003
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
PITARD BRUNO (FR)
PITARD BRUNO (FR)
International Classes:
A61K31/7088; A61K31/77; A61K31/785; A61K47/04; A61K38/16; A61K38/46; A61K47/34; A61K48/00; A61P21/00; A61P43/00; (IPC1-7): A61K48/00; A61K31/785; A61K31/77
Domestic Patent References:
| WO2001065911A2 | 2001-09-13 | |||
| WO2000047186A1 | 2000-08-17 | |||
| WO1993015745A1 | 1993-08-19 | |||
| WO1996015778A1 | 1996-05-30 | |||
| WO2000051645A1 | 2000-09-08 | |||
| WO1996021470A2 | 1996-07-18 | |||
| WO2001008709A1 | 2001-02-08 | |||
| WO1999031262A2 | 1999-06-24 | |||
| WO2001060415A1 | 2001-08-23 | |||
| WO2002061040A2 | 2002-08-08 |
Foreign References:
| US6221959B1 | 2001-04-24 |
Other References:
KLEBE R J ET AL: "UPTAKE BY CELLS OF NUCLEIC ACIDS PROMOTED BY COMPOUNDS SHARING THE PLEIOTROPIC EFFECTS OF POLY(ETHYLENE GLYCOL)", TERATOGENESIS, CARCINOGENESIS, MUTAGENESIS, ALAN R. LISS, NEW YORK, NY, US, vol. 6, no. 3, 1986, pages 245 - 250, XP000572777, ISSN: 0270-3211
PROKOP ALES ET AL: "Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, no. 1, January 2002 (2002-01-01), pages 67 - 76, XP002253712, ISSN: 0022-3549
KAKIZAWA Y ET AL: "BLOCK COPOLYMER MICELLES FOR DELIVERY OF GENE AND RELATED COMPOUNDS", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 54, 2002, pages 203 - 222, XP001150717, ISSN: 0169-409X
PROKOP ALES ET AL: "Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, no. 1, January 2002 (2002-01-01), pages 67 - 76, XP002253712, ISSN: 0022-3549
KAKIZAWA Y ET AL: "BLOCK COPOLYMER MICELLES FOR DELIVERY OF GENE AND RELATED COMPOUNDS", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 54, 2002, pages 203 - 222, XP001150717, ISSN: 0169-409X
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