POLYPEPTIDE, OXYGENASE, AND USE APPLICATIONS THEREOF

WIPO Patent Application WO/2024/004921

A1

The present invention addresses the problem of providing a modified oxygenase capable of epoxidating specifically only the position-ω3 in a highly unsaturated fatty acid. The present invention relates to: a polypeptide comprising an amino acid sequence having such a structure that one or more amino acid residues selected from the group consisting of F87K/I/H, A330V, P25L and T438M are substituted in the amino acid sequence represented by SEQ ID NO:2; and a polypeptide that is substantially the same as the aforementioned polypeptide.

ISHIHARA SATORU (JP)
KOIKEDA SATOSHI (JP)
KAMEDA TOMOSHI (JP)
IKEBE KIMIYOSHI (JP)
KURUMIDA YOICHI (JP)
OGAWA JUN (JP)
HARA RYOTARO (JP)
KISHINO SHIGENOBU (JP)
TAKEUCHI MICHIKI (JP)
ANDO AKINORI (JP)

PCT/JP2023/023517

January 04, 2024

June 26, 2023

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AMANO ENZYME INC (JP)
AIST (JP)
UNIV KYOTO (JP)

C12N15/53; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12N9/08; C12N15/63; C12P7/6409

WO2012023254A1	2012-02-23
WO2010070086A2	2010-06-24

JP2003521889A	2003-07-22
JP2015534831A	2015-12-07
US20160355852A1	2016-12-08

OLIVER C F ET AL: "A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation.", BIOCHEMISTRY, vol. 36, 1 January 1997 (1997-01-01), pages 1567 - 1572, XP002131694, ISSN: 0006-2960, DOI: 10.1021/bi962826c

SIKS & CO. (JP)

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