Title:
POLYSACCHARIDE HAVING NATURAL IMMUNOSTIMULATORY ACTION AND NATURAL IMMUNOSTIMULANT OR FOOD OR DRINK COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2018/030542
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel substance having a natural immunostimulatory action. Provided are: a polysaccharide having a natural immunostimulatory action, characterized by comprising, as constituent saccharides, 25-50 parts by mol of galacturonic acid, 15-50 parts by mol of galactose, 0-7 parts by mol of glucose, 0-30 parts by mol of arabinose, 0-6 parts by mol of xylose and 3-15 parts by mol of rhamnose, and having, as the main chain, a polygalacturonic acid chain consisting of galacturonic acid residues linked by α-1,4-bonds; a natural immunostimulant which comprises the polysaccharide as an active ingredient; and a food or a drink comprising the polysaccharide.
Inventors:
SEKIMIZU KAZUHISA (JP)
URAI MAKOTO (JP)
URAI MAKOTO (JP)
Application Number:
PCT/JP2017/029237
Publication Date:
February 15, 2018
Filing Date:
August 04, 2017
Export Citation:
Assignee:
IMAGINE GLOBAL CARE CORP (JP)
International Classes:
C08B37/00; A23L33/125; A61K31/715; A61P37/04; A23L19/00
Domestic Patent References:
| WO2008126905A1 | 2008-10-23 | |||
| WO2008126905A1 | 2008-10-23 |
Foreign References:
| JPH0476003A | 1992-03-10 | |||
| JPH0379602A | 1991-04-04 | |||
| JPH0245501A | 1990-02-15 |
Other References:
HIROKI KINOSHITA ET AL.: "Exploratory Trial Concerning Activation of Human Natural Immunity by Continued Consumption of a Broccoli Extract Processed Food Product", BASIC PHARMACOLOGY & THERAPEUTICS, vol. 40, no. 6, 2012, pages 489 - 494
BAO-HUI, C. ET AL.: "Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata", CARBOHYDR POLYM, vol. 103, 2014, pages 244 - 249, XP028613154
MINGCHUN, W. ET AL.: "Preparation, preliminary characterization and immunostimulatory activity of polysaccharide fractions from the peduncles of Hovenia dulcis", FOOD CHEM, vol. 138, no. 1, 2013, pages 41 - 47, XP055332350
SAPHALA, D. ET AL.: "Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay", DRUG DISCOV THER, vol. 5, no. 1, 2011, pages 18 - 25, XP055110260
ISHII K; HAMAMOTO H; KAMIMURA M; SEKIMIZU K., J BIOL CHEM., vol. 283, no. 4, 2008, pages 2185 - 91
ISHII K; HAMAMOTO H; KAMIMURA M; NAKAMURA Y; NODA H; IMAMURA K; MITA K; SEKIMIZU K., J BIOL CHEM., vol. 285, no. 37, 2010, pages 28635 - 42
ISHII K; HAMAMOTO H; IMAMURA K; ADACHI T; SHOJI M; NAKAYAMA K; SEKIMIZU K., J BIOL CHEM., vol. 285, no. 43, 2010, pages 33338 - 47
DHITAL S; HAMAMOTO H; URAI M; ISHII K; SEKIMIZU K., DRUG DISCOVERIES & THERAPEUTICS, vol. 5, no. 1, 2011, pages 18 - 15
T. FUJIYUKI; H. HAMAMOTO; K. ISHII; M. URAI; K. KATAOKA; T. TAKEDA; S. SHIBATA; K. SEKIMIZU, DRUG DISCOVERIES & THERAPEUTICS, vol. 6, no. 2, 2012, pages 88 - 93
See also references of EP 3498737A4
BAO-HUI, C. ET AL.: "Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata", CARBOHYDR POLYM, vol. 103, 2014, pages 244 - 249, XP028613154
MINGCHUN, W. ET AL.: "Preparation, preliminary characterization and immunostimulatory activity of polysaccharide fractions from the peduncles of Hovenia dulcis", FOOD CHEM, vol. 138, no. 1, 2013, pages 41 - 47, XP055332350
SAPHALA, D. ET AL.: "Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay", DRUG DISCOV THER, vol. 5, no. 1, 2011, pages 18 - 25, XP055110260
ISHII K; HAMAMOTO H; KAMIMURA M; SEKIMIZU K., J BIOL CHEM., vol. 283, no. 4, 2008, pages 2185 - 91
ISHII K; HAMAMOTO H; KAMIMURA M; NAKAMURA Y; NODA H; IMAMURA K; MITA K; SEKIMIZU K., J BIOL CHEM., vol. 285, no. 37, 2010, pages 28635 - 42
ISHII K; HAMAMOTO H; IMAMURA K; ADACHI T; SHOJI M; NAKAYAMA K; SEKIMIZU K., J BIOL CHEM., vol. 285, no. 43, 2010, pages 33338 - 47
DHITAL S; HAMAMOTO H; URAI M; ISHII K; SEKIMIZU K., DRUG DISCOVERIES & THERAPEUTICS, vol. 5, no. 1, 2011, pages 18 - 15
T. FUJIYUKI; H. HAMAMOTO; K. ISHII; M. URAI; K. KATAOKA; T. TAKEDA; S. SHIBATA; K. SEKIMIZU, DRUG DISCOVERIES & THERAPEUTICS, vol. 6, no. 2, 2012, pages 88 - 93
See also references of EP 3498737A4
Download PDF: