PREPARATION METHOD FOR (4-ISOPROPOXY-2-METHYL) PHENYL ISOPROPYL KETONE

Title:

PREPARATION METHOD FOR (4-ISOPROPOXY-2-METHYL) PHENYL ISOPROPYL KETONE

Document Type and Number:

WIPO Patent Application WO/2021/238839

Kind Code:

A1

Abstract:

Disclosed is a preparation method for (4-isopropoxy-2-methyl) phenyl isopropyl ketone, comprising: reacting m-cresol and thiocyanate under the action of a catalyst to obtain a product A; reacting the product A and halogenated isopropane under the action of alkali and the catalyst to obtain a product B; and reacting the product B and isopropyl magnesium halide for treatment to obtain the (4-isopropoxy-2-methyl) phenyl isopropyl ketone. The purity of the (4-isopropoxy-2-methyl) phenyl isopropyl ketone prepared by the steps is more than 99%, and the total yield is more than 79%. The method avoids the use of a toxic reagent and the generation of a large amount of acidic wastewater, lowers the reaction temperature, increases the reaction yield, has a simple and efficient process route, and reduces costs; and the obtained product has high purity. The method greatly improves the production safety, and is easy for industrialized popularization.

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Inventors:

LIU WEI (CN)
WU SHAOXIANG (CN)
GAO RUI (CN)
WANG RUI (CN)
WANG WENJUN (CN)

Application Number:

PCT/CN2021/095446

Publication Date:

December 02, 2021

Filing Date:

May 24, 2021

Export Citation:

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Assignee:

ADAMA MAKHTESHIM LTD (IL)
LIU WEI (CN)

International Classes:

C07C253/00; C07C255/53

Domestic Patent References:

WO2006016708A1

2006-02-16

Foreign References:

CN111548257A	2020-08-18
JP2016108332A	2016-06-20
CN102741227A	2012-10-17
CN111132976A	2020-05-08

Other References:

SARDARIAN ALI REZA, DINDARLOO INALOO IMAN, MODARRESI-ALAM ALI REZA, KLEINPETER ERICH, SCHILDE UWE: "Metal-Free Regioselective Monocyanation of Hydroxy-, Alkoxy-, and Benzyloxyarenes by Potassium Thiocyanate and Silica Sulfuric Acid as a Cyanating Agent", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 84, no. 4, 15 February 2019 (2019-02-15), pages 1748 - 1756, XP055872716, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b02191

Attorney, Agent or Firm:

BEIJING CAI HE LAW FIRM (CN)

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